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dc.rights.licenseopenen_US
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorVANCAPPEL, Alexis
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDANSOU, Yecodji
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorYRONDI, Antoine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSTEPHAN, Florian
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorRICHIERI, Raphaelle Marie
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMOLIERE, Fanny
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHOLTZMANN, Jerome
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHORN, Mathilde
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorALLAUZE, Etienne
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGENTY, Jean Baptiste
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alex
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDOREY, Jean-Michel
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorHENNION, Vincent
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCAMUS, Vincent
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorFOND, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPERAN, Barbara
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorWALTER, Michel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorANGUILL, Loic
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSCOTTO D'APOLINA, Charlotte
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorVILA, Estelle
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorFREDEMBACH, Benjamin
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPETRUCCI, Jean
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorREY, Romain
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorNGUON, Anne Sophie
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S_1144 / U1144)]
dc.contributor.authorETAIN, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCARMINATI, Mathilde
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorVAIVA, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLLORCA, Pierre Michel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBENNABI, Djamila
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorEL HAGE, Wissam
dc.date.accessioned2023-10-11T14:06:22Z
dc.date.available2023-10-11T14:06:22Z
dc.date.issued2023-07-24
dc.identifier.issn2076-3425en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184389
dc.description.abstractEnPrevious studies set out profound cognitive impairments in subjects with treatment-resistant depression (TRD). However, little is known about the course of such alterations depending on levels of improvement in those patients followed longitudinally. The main objective of this study was to describe the course of cognitive impairments in responder versus non-responder TRD patients at one-year follow-up. The second aim was to evaluate the predictive aspect of cognitive impairments to treatment resistance in patients suffering from TRD. We included 131 patients from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centers. They undertook comprehensive sociodemographic, clinical, global functioning, and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16) at baseline (V0) and one-year follow-up (V1). Most patients ( = 83; 63.36%) did not respond (47 women, 49.47 ± 12.64 years old), while one-third of patients responded ( = 48, 30 women, 54.06 ± 12.03 years old). We compared the cognitive performances of participants to average theoretical performances in the general population. In addition, we compared the cognitive performances of patients between V1 and V0 and responder versus non-responder patients at V1. We observed cognitive impairments during the episode and after a therapeutic response. Overall, each of them tended to show an increase in their cognitive scores. Improvement was more prominent in responders at V1 compared to their non-responder counterparts. They experienced a more marked improvement in code, digit span, arithmetic, similarities, and D2 tasks. Patients suffering from TRD have significant cognitive impairments that persist but alleviate after therapeutic response. Cognitive remediation should be proposed after therapeutic response to improve efficiency and increase the daily functioning.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCognitive impairments
dc.subject.enExecutive function
dc.subject.enMemory
dc.subject.enNeuropsychology
dc.subject.enProcessing speed
dc.subject.enTreatment-resistant depression
dc.title.enEvolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort.
dc.title.alternativeBrain Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/brainsci13071120en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37509050en_US
bordeaux.journalBrain Sciencesen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04237649
hal.version1
hal.date.transferred2023-10-11T14:06:27Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain%20Sciences&rft.date=2023-07-24&rft.volume=13&rft.issue=7&rft.eissn=2076-3425&rft.issn=2076-3425&rft.au=VANCAPPEL,%20Alexis&DANSOU,%20Yecodji&GODIN,%20Ophelia&HAFFEN,%20Emmanuel&YRONDI,%20Antoine&rft.genre=article


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