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Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBENOIT, Simon
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHENRY, Mathilde
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
hal.structure.identifierBiologie de la Reproduction, Environnement, Epigénétique & Développement [BREED]
dc.contributor.authorFNEICH, Sara
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMATHOU, Alexia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorXIA, Lin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFOURY, Aline
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
hal.structure.identifierBiologie de la Reproduction, Environnement, Epigénétique & Développement [BREED]
dc.contributor.authorJOUIN, Mélanie
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
hal.structure.identifierBiologie de la Reproduction, Environnement, Epigénétique & Développement [BREED]
dc.contributor.authorJUNIEN, Claudine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
hal.structure.identifierBiologie de la Reproduction, Environnement, Epigénétique & Développement [BREED]
dc.contributor.authorJOUNEAU, Luc
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie-Pierre
hal.structure.identifierCentre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP]
dc.contributor.authorDELPIERRE, Cyrille
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
hal.structure.identifierBiologie de la Reproduction, Environnement, Epigénétique & Développement [BREED]
dc.contributor.authorGABORY, Anne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
dc.date.accessioned2023-10-10T12:36:04Z
dc.date.available2023-10-10T12:36:04Z
dc.date.issued2023-01-01
dc.identifier.issn2296-861Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184373
dc.description.abstractEnIn humans, adversity in childhood exerts enduring effects on brain and increases the vulnerability to psychiatric diseases. It also leads to a higher risk of eating disorders and obesity. Maternal separation (MS) in mice has been used as a of stress during infancy. We hypothesized that MS in mice affects motivation to obtain palatable food in adulthood and changes gene expression in reward system. Male and female pups from C57Bl/6J and C3H/HeN mice strains were subjected to a daily MS protocol from postnatal day (PND) 2 to PND14. At adulthood, their motivation for palatable food reward was assessed in operant cages. Compared to control mice, male and female C3H/HeN mice exposed to MS increased their instrumental response for palatable food, especially when the effort required to obtain the reward was high. Importantly, this effect is shown in animals fed . Transcriptional analysis revealed 375 genes differentially expressed in the nucleus accumbens of male MS C3H/HeN mice compared to the control group, some of these being associated with the regulation of the reward system (e.g., , ). Interestingly, C57Bl/6J mice exposed to MS did not show alterations in their motivation to obtain a palatable reward, nor significant changes in gene expression in the nucleus accumbens. MS produces long-lasting changes in motivation for palatable food in C3H/HeN mice, but has no impact in C57Bl/6J mice. These behavioral alterations are accompanied by drastic changes in gene expression in the nucleus accumbens, a key structure in the regulation of motivational processes.
dc.description.sponsorshipEnvironnement psychosocial précoce, empreintes biologiques et épigénétiques et état de santé à l'âge adulte - ANR-12-DSSA-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enEarly life stress
dc.subject.enSex effect
dc.subject.enOperant conditioning
dc.subject.enMesolimbic circuit
dc.subject.enC3H/HeN mice
dc.title.enStrain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.
dc.title.alternativeFront Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fnut.2023.1190392en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37565037en_US
bordeaux.journalFrontiers in Nutritionen_US
bordeaux.page1190392en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Nutrition&rft.date=2023-01-01&rft.volume=10&rft.spage=1190392&rft.epage=1190392&rft.eissn=2296-861X&rft.issn=2296-861X&rft.au=BENOIT,%20Simon&HENRY,%20Mathilde&FNEICH,%20Sara&MATHOU,%20Alexia&XIA,%20Lin&rft.genre=article


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