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Lung Tumor Growth Promotion by Tobacco-Specific Nitrosamines Involves the β2-Adrenergic Receptors-Dependent Stimulation of Mitochondrial REDOX Signaling.

dc.rights.licenseopenen_US
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorSARLAK, Saharnaz
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorLALOU, Claude
dc.contributor.authorSANT'ANNA-SILVA, Ana Carolina B
dc.contributor.authorMAFHOUF, Walid
dc.contributor.authorDE LUISE, Monica
dc.contributor.authorROUSSEAU, Benoit
dc.contributor.authorIZOTTE, Julien
dc.contributor.authorCLAVEROL, Stéphane
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorLACOMBE, Didier
dc.contributor.authorNIKITOPOULOU, Efterpi
dc.contributor.authorYANG, Ming
dc.contributor.authorOLIVEIRA, Marcus
dc.contributor.authorFREZZA, Christian
dc.contributor.authorGASPARRE, Giuseppe
dc.contributor.authorREZVANI, Hamid Reza
hal.structure.identifierCentre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorAMOEDO, Nivea Dias
hal.structure.identifierBiothérapies des maladies génétiques et cancers
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierCentre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB]
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorROSSIGNOL, Rodrigue
dc.date.accessioned2023-09-29T10:26:57Z
dc.date.available2023-09-29T10:26:57Z
dc.date.issued2022-03-01
dc.identifier.issn1557-7716en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183831
dc.description.abstractEnLung cancer is the leading cause of cancer death worldwide, and tobacco smoking is a recognized major risk factor for lung tumor development. We analyzed the effect of tobacco-specific nitrosamines (TSNAs) on human lung adenocarcinoma metabolic reprogramming, an emergent hallmark of carcinogenesis. A series of and bioenergetic, proteomic, metabolomic, and tumor biology studies were performed to analyze changes in lung cancer cell metabolism and the consequences for hallmarks of cancer, including tumor growth, cancer cell invasion, and redox signaling. The findings revealed that nicotine-derived nitrosamine ketone (NNK) stimulates mitochondrial function and promotes lung tumor growth . These malignant properties were acquired from the induction of mitochondrial biogenesis induced by the upregulation and activation of the beta-2 adrenergic receptors (β2-AR)-cholinergic receptor nicotinic alpha 7 subunit (CHRNAα7)-dependent nitrosamine canonical signaling pathway. The observed NNK metabolic effects were mediated by TFAM overexpression and revealed a key role for mitochondrial reactive oxygen species and Annexin A1 in tumor growth promotion. Conversely, ectopic expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase rescued the reprogramming and malignant metabolic effects of exposure to NNK and overexpression of TFAM, underlining the link between NNK and mitochondrial redox signaling in lung cancer. Our findings describe the metabolic changes caused by NNK in a mechanistic framework for understanding how cigarette smoking causes lung cancer. Mitochondria play a role in the promotion of lung cancer induced by tobacco-specific nitrosamines. 36, 525-549.
dc.language.isoENen_US
dc.subjectBioenergetics
dc.subjectCancer
dc.subjectLung
dc.subjectMitochondria
dc.subjectRedox
dc.subjectTobacco
dc.title.enLung Tumor Growth Promotion by Tobacco-Specific Nitrosamines Involves the β2-Adrenergic Receptors-Dependent Stimulation of Mitochondrial REDOX Signaling.
dc.title.alternativeARSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/ars.2020.8259en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed34715750en_US
bordeaux.journalAntioxidants and Redox Signalingen_US
bordeaux.page525-549en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesMaladies Rares : Génétique et Métabolisme (MRGM) - UMR 1211en_US
bordeaux.issue7-9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04222667
hal.version1
hal.date.transferred2023-09-29T10:27:05Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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