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Diurnal symptoms of sleepiness and dysfunction predict future suicidal ideation in a French cohort of outpatients (FACE-DR) with treatment resistant depression: A 1-year prospective study about sleep markers

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMARUANI, Julia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMOLIÈRE, Fanny
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorYRONDI, Antoine
dc.contributor.authorBENNABI, Djamila
dc.contributor.authorRICHIERI, Raphaelle
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorEL-HAGE, Wissan
dc.contributor.authorALLAUZE, Etienne
dc.contributor.authorANGUILL, Loic
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alexandra
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorCAMUS, Vincent
dc.contributor.authorDOREY, Jean-Michel
dc.contributor.authorETAIN, Bruno
dc.contributor.authorFOND, Guillaume
dc.contributor.authorGENTY, Jean-Baptiste
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorHOLTZMANN, Jérôme
dc.contributor.authorHORN, Mathilde
dc.contributor.authorKAZOUR, François
dc.contributor.authorNGUON, Anne-Sophie
dc.contributor.authorPETRUCCI, Jean
dc.contributor.authorREY, Romain
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorVAIVA, Guillaume
dc.contributor.authorWALTER, Michel
dc.contributor.authorLEJOYEUX, Michel
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
dc.contributor.authorGEOFFROY, Pierre A.
dc.date.accessioned2023-09-29T08:53:58Z
dc.date.available2023-09-29T08:53:58Z
dc.date.issued2023-05-01
dc.identifier.issn0165-0327en_US
dc.identifier.urioai:crossref.org:10.1016/j.jad.2023.02.106
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183830
dc.description.abstractEnBackground : Patients suffering from treatment-resistant depression (TRD) are at risk of suicide. Sleep and circadian rhythm alterations are widely recognized as core symptoms of major depressive disorder and are associated with suicidal ideation. Thus, sleep and circadian rhythm alterations may be targeted to prevent suicide. Methods: Patients were recruited from a prospective cohort of the French network of TRD expert centers. Mood, sleep and circadian rhythms were assessed at baseline; suicidal risk was assessed both at baseline and during a one-year follow-up with standardized subjective questionnaires. Results : Excessive daytime sleepiness (adjusted odds ratio aOR = 1.7(1–3.3), p = 0.04) and daytime dysfunction (aOR = 1.81(1.16–2.81), p = 0.0085) increased the risk of suicidal thoughts over the one-year follow-up period in patients with TRD after adjustment on age, gender, depression, trauma, anxiety, impulsivity, current daily tobacco smoking and body mass index. Hypnotics intake is associated with a reduced risk of suicidal ideation at one-year follow-up after the same adjustments (OR = 0.73(0.56–0.95), p = 0.019). Other associations between sleep quality or circadian rhythms and suicidal ideations at either baseline or one year did not remain significant in multivariate analyses after the same adjustments. Limitations : Sleep assessments were based on self-reported questionnaires rather than objective measures. Conclusions : Daytime sleepiness and dysfunction are predictors of suicidal ideations, whereas hypnotics intake is associated with a reduced risk of suicidal ideations. Diurnal symptoms of sleep disturbances are therefore red flags to target for preventing suicide in depressed patients, and hypnotics seem efficient in preventing suicide for patients with TRD.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.sourcecrossref
dc.title.enDiurnal symptoms of sleepiness and dysfunction predict future suicidal ideation in a French cohort of outpatients (FACE-DR) with treatment resistant depression: A 1-year prospective study about sleep markers
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2023.02.106en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36842655en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page369-378en_US
bordeaux.volume329en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAstraZenecaen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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