| dc.rights.license | open | en_US |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | MONTALBAN, Enrica | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | WALLE, Roman | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | CASTEL, Julien | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | ANSOULT, Anthony | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | HASSOUNA, Rim | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | FOPPEN, Ewout | |
| dc.contributor.author | FANG, Xi | |
| dc.contributor.author | HUTELIN, Zach | |
| dc.contributor.author | MICKUS, Sophie | |
| dc.contributor.author | PERSZYK, Emily | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PETITBON, Anna | |
| dc.contributor.author | BERTHELET, Jérémy | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | RODRIGUES-LIMA, Fernando | |
| dc.contributor.author | CEBRIAN-SERRANO, Alberto | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | GANGAROSSA, Giuseppe | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | MARTIN, Claire | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | TRIFILIEFF, Pierre | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BOSCH-BOUJU, Clémentine | |
| dc.contributor.author | SMALL, Dana M. | |
| dc.contributor.author | LUQUET, Serge | |
| dc.date.accessioned | 2023-09-26T13:45:59Z | |
| dc.date.available | 2023-09-26T13:45:59Z | |
| dc.date.issued | 2023-02-01 | |
| dc.identifier.issn | 0006-3223 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1016/j.biopsych.2023.02.010 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183801 | |
| dc.description.abstractEn | Background: A large body of evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the TaqIA polymorphism is one of the most commonly studied in psychiatry. TaqIA is located in the gene that codes for the ankyrin repeat and kinase domain containing 1 kinase (Ankk1) near the dopamine D2 receptor (D2R) gene. Homozygous expression of the A1 allele correlates with a 30% to 40% reduction of striatal D2R, a typical feature of addiction, overeating, and other psychiatric pathologies. The mechanisms by which the variant influences dopamine signaling and behavior are unknown. Methods: Here, we used transgenic and viral-mediated strategies to reveal the role of Ankk1 in the regulation of activity and functions of the striatum. Results: We found that Ankk1 is preferentially enriched in striatal D2R-expressing neurons and that Ankk1 loss of function in the dorsal and ventral striatum leads to alteration in learning, impulsivity, and flexibility resembling endophenotypes described in A1 carriers. We also observed an unsuspected role of Ankk1 in striatal D2R-expressing neurons of the ventral striatum in the regulation of energy homeostasis and documented differential nutrient partitioning in humans with or without the A1 allele. Conclusions: Overall, our data demonstrate that the Ankk1 gene is necessary for the integrity of striatal functions and reveal a new role for Ankk1 in the regulation of body metabolism. | |
| dc.description.sponsorship | Altérations du système de récompense dans l'anorexie mentale - ANR-19-CE37-0020 | en_US |
| dc.description.sponsorship | Role du biostatus en acides gras polyinsaturés dans les troubles de contrôle exécutif | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject.en | D(2)R receptor | |
| dc.subject.en | Dopamine signaling | |
| dc.subject.en | Eating disorders | |
| dc.subject.en | Genetic polymorphism | |
| dc.subject.en | Metabolism | |
| dc.subject.en | Reward-associated behavior | |
| dc.title.en | The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D2 Receptor-Expressing Neurons | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biopsych.2023.02.010 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36805080 | en_US |
| bordeaux.journal | Biological Psychiatry | en_US |
| bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
| bordeaux.import.source | dissemin | |
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| hal.popular | non | en_US |
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| dc.rights.cc | CC BY-NC-ND | en_US |
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