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Axo-axonic cells in neuropsychiatric disorders: a systematic review.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | VIVIEN, Juliette | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS] | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | EL AZRAOUI, Anass | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LHERAUX, Cloé | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LANORE, Frederic | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | AOUIZERATE, Bruno
IDREF: 069471851 | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | HERRY, Cyril | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS] | |
| dc.contributor.author | HUMEAU, Yann | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BIENVENU, Thomas C. M. | |
| dc.date.accessioned | 2023-09-21T14:52:49Z | |
| dc.date.available | 2023-09-21T14:52:49Z | |
| dc.date.issued | 2023-06-26 | |
| dc.identifier.issn | 1662-5102 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183760 | |
| dc.description.abstractEn | Imbalance between excitation and inhibition in the cerebral cortex is one of the main theories in neuropsychiatric disorder pathophysiology. Cortical inhibition is finely regulated by a variety of highly specialized GABAergic interneuron types, which are thought to organize neural network activities. Among interneurons, axo-axonic cells are unique in making synapses with the axon initial segment of pyramidal neurons. Alterations of axo-axonic cells have been proposed to be implicated in disorders including epilepsy, schizophrenia and autism spectrum disorder. However, evidence for the alteration of axo-axonic cells in disease has only been examined in narrative reviews. By performing a systematic review of studies investigating axo-axonic cells and axo-axonic communication in epilepsy, schizophrenia and autism spectrum disorder, we outline convergent findings and discrepancies in the literature. Overall, the implication of axo-axonic cells in neuropsychiatric disorders might have been overstated. Additional work is needed to assess initial, mostly indirect findings, and to unravel how defects in axo-axonic cells translates to cortical dysregulation and, in turn, to pathological states. | |
| dc.description.sponsorship | University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Autism | |
| dc.subject.en | Chandelier cell | |
| dc.subject.en | Epilepsy | |
| dc.subject.en | Interneuron | |
| dc.subject.en | Schizophrenia | |
| dc.title.en | Axo-axonic cells in neuropsychiatric disorders: a systematic review. | |
| dc.title.alternative | Front Cell Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fncel.2023.1212202 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 37435048 | en_US |
| bordeaux.journal | Frontiers in Cellular Neuroscience | en_US |
| bordeaux.volume | 17 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | INRAE | |
| bordeaux.team | Circuits neuronaux des apprentissages associatifs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation Bettencourt Schueller | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Cellular%20Neuroscience&rft.date=2023-06-26&rft.volume=17&rft.eissn=1662-5102&rft.issn=1662-5102&rft.au=VIVIEN,%20Juliette&EL%20AZRAOUI,%20Anass&LHERAUX,%20Clo%C3%A9&LANORE,%20Frederic&AOUIZERATE,%20Bruno&rft.genre=article |
