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Virological failure of patients on maraviroc-based antiretroviral therapy
| dc.contributor.author | RAYMOND, Stéphanie | |
| dc.contributor.author | MAILLARD, Anne | |
| dc.contributor.author | AMIEL, Corinne | |
| dc.contributor.author | PEYTAVIN, Gilles | |
| dc.contributor.author | TRABAUD, Mary Anne | |
| dc.contributor.author | DESBOIS, Delphine | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BELLECAVE, Pantxika | |
| dc.contributor.author | DELAUGERRE, Constance | |
| dc.contributor.author | SOULIE, Cathia | |
| dc.contributor.author | MARCELIN, Anne Geneviève | |
| dc.contributor.author | DESCAMPS, Diane | |
| dc.contributor.author | IZOPET, Jacques | |
| dc.date.accessioned | 2023-07-18T08:29:57Z | |
| dc.date.available | 2023-07-18T08:29:57Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 0305-7453 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183422 | |
| dc.description.abstractEn | OBJECTIVES: Virological failure (VF) in patients on maraviroc-based treatment has been associated with altered HIV tropism and resistance to maraviroc. This multicentre study aimed to characterize VF in patients treated with maraviroc. METHODS: We analysed 27 patients whose treatment failed between 2008 and 2011. They had been screened for HIV tropism before maraviroc initiation using population-based V3 genotyping. HIV-1 tropism and resistance of R5 viruses to maraviroc at VF and at baseline were determined retrospectively using an ultrasensitive recombinant virus assay (RVA). RESULTS: Viruses from 27 patients given maraviroc on the basis of the R5 genotype were characterized at the time of treatment failure. The RVA indicated that 12 patients harboured CXCR4-using viruses and 15 (56%) had pure R5 viruses at failure. One-third of those harbouring CXCR4-using viruses (4/12) were infected with R5X4/X4 viruses according to the RVA before maraviroc initiation. We analysed the phenotypic resistance to maraviroc of four patients harbouring R5 viruses at failure; two harboured viruses whose maximum percentage inhibition was reduced by 65%-90%, while the other two were infected with susceptible viruses. All patients had effective concentrations of drugs. CONCLUSIONS: Half of the maraviroc-treated patients who experienced VF harboured CXCR4-using viruses at failure, one-third of them were detected by a phenotypic method before maraviroc initiation. Phenotypic assessment of R5 virus resistance to CCR5 antagonists at failure could help optimize antiretroviral therapy | |
| dc.language.iso | en | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.subject.en | Adult | |
| dc.subject.en | Aged | |
| dc.subject.en | Anti-Retroviral Agents | |
| dc.subject.en | Antiretroviral Therapy | |
| dc.subject.en | Highly Active | |
| dc.subject.en | CXCR4 | |
| dc.subject.en | Cyclohexanes | |
| dc.subject.en | Drug Resistance | |
| dc.subject.en | Viral | |
| dc.subject.en | entry | |
| dc.subject.en | Female | |
| dc.subject.en | HIV-1 | |
| dc.subject.en | HIV-1 tropism determination | |
| dc.subject.en | HIV Infections | |
| dc.subject.en | Humans | |
| dc.subject.en | Male | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | phenotypic assay | |
| dc.subject.en | resistance to maraviroc | |
| dc.subject.en | Retrospective Studies | |
| dc.subject.en | Treatment Failure | |
| dc.subject.en | Triazoles | |
| dc.subject.en | Viral Load | |
| dc.subject.en | Viral Tropism | |
| dc.title.en | Virological failure of patients on maraviroc-based antiretroviral therapy | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/jac/dkv026 | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| bordeaux.page | 1858--1864 | |
| bordeaux.volume | 70 | |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 6 | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| bordeaux.import.source | hal | |
| hal.identifier | hal-01274888 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2015&rft.volume=70&rft.issue=6&rft.spage=1858--1864&rft.epage=1858--1864&rft.eissn=0305-7453&rft.issn=0305-7453&rft.au=RAYMOND,%20St%C3%A9phanie&MAILLARD,%20Anne&AMIEL,%20Corinne&PEYTAVIN,%20Gilles&TRABAUD,%20Mary%20Anne&rft.genre=article |
