Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | KAMINSKI, Hannah | |
| hal.structure.identifier | Service de virologie et d'immunologie biologique | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | GARRIGUE, Isabelle
IDREF: 12258953X | |
| hal.structure.identifier | CHU Bordeaux | |
| dc.contributor.author | COUZI, Lionel | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | TATON, Benjamin | |
| hal.structure.identifier | CHU Bordeaux | |
| dc.contributor.author | BACHELET, Thomas | |
| hal.structure.identifier | Composantes innées de la réponse immunitaire et différenciation [CIRID] | |
| dc.contributor.author | MOREAU, Jean-François | |
| hal.structure.identifier | Composantes innées de la réponse immunitaire et différenciation [CIRID] | |
| dc.contributor.author | DECHANET-MERVILLE, Julie
IDREF: 061667994 | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Epidémiologie et Biostatistique [Bordeaux] | |
| dc.contributor.author | THIÉBAUT, Rodolphe | |
| hal.structure.identifier | Service de Néphrologie-transplantation-dialyse [Bordeaux] | |
| dc.contributor.author | MERVILLE, Pierre | |
| dc.date.accessioned | 2023-07-18T08:21:33Z | |
| dc.date.available | 2023-07-18T08:21:33Z | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 1046-6673 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183421 | |
| dc.description.abstractEn | Cytomegalovirus (CMV) infection in solid-organ transplantation is associated with increased morbidity and mortality, particularly if a CMV mutant strain with antiviral resistance emerges. Monitoring CMV-specific T cell response could provide relevant information for patient care. We and others have shown the involvement of Vδ2(neg) γδ T cells in controlling CMV infection. Here, we assessed if Vδ2(neg) γδ T cell kinetics in peripheral blood predict CMV infection resolution and emergence of a mutant strain in high-risk recipients of kidney transplants, including 168 seronegative recipients receiving organs from seropositive donors (D+R-) and 104 seropositive recipients receiving antithymocyte globulins (R+/ATG). Vδ2(neg) γδ T cell percentages were serially determined in patients grafted between 2003 and 2011. The growing phase of Vδ2(neg) γδ T cells was monitored in each infected patient, and the expansion rate during this phase was estimated individually by a linear mixed model. A Vδ2(neg) γδ T cell expansion rate of ˃0.06% per day predicted the growing phase. The time after infection at which an expansion rate of 0.06% per day occurred was correlated with the resolution of CMV DNAemia (r=0.91; P<0.001). At 49 days of antiviral treatment, Vδ2(neg) γδ T cell expansion onset was associated with recovery, whereas absence of expansion was associated with recurrent disease and DNAemia. The appearance of antiviral-resistant mutant CMV strains was associated with delayed Vδ2(neg) γδ T cell expansion (P<0.001). In conclusion, longitudinal surveillance of Vδ2(neg) γδ T cells in recipients of kidney transplants may predict CMV infection resolution and antiviral drug resistance. | |
| dc.language.iso | en | |
| dc.publisher | American Society of Nephrology | |
| dc.title.en | Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants. | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1681/ASN.2014100985 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
| bordeaux.page | 637-645 | |
| bordeaux.volume | 27 | |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 2 | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| bordeaux.import.source | hal | |
| hal.identifier | hal-01164667 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
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