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Viremia Copy-Years as a Predictive Marker of All-Cause Mortality in HIV-1-Infected Patients Initiating a Protease Inhibitor-Containing Antiretroviral Treatment.

dc.rights.licenseopenen_US
dc.contributor.authorCHIROUZE, Catherine
hal.structure.identifierEpidémiologie et Biostatistique [Bordeaux]
dc.contributor.authorJOURNOT, Valérie
dc.contributor.authorLE MOING, Vincent
dc.contributor.authorRAFFI, François
dc.contributor.authorPIROTH, Lionel
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorREIGADAS, Sandrine
dc.contributor.authorCASSUTO, Jill-Patrice
hal.structure.identifierEpidémiologie et Biostatistique [Bordeaux]
dc.contributor.authorCHÊNE, Geneviève
dc.contributor.authorLEPORT, Catherine
dc.contributor.authorHOEN, Bruno
dc.date.accessioned2023-07-13T12:23:20Z
dc.date.available2023-07-13T12:23:20Z
dc.date.issued2015-02-01
dc.identifier.issn1525-4135en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183397
dc.description.abstractEnViremia copy-years (VCY) has been reported as a short-term predictor of mortality. We evaluated the association of this parameter with 10-year outcome within the APROCO-COPILOTE cohort. Prospective data from 1281 HIV-1-infected patients who started a first protease inhibitor-containing regimen in 1997-1999 were analyzed. Patients with baseline plasma viral load (pVL) > 500 copies per milliliter and at least 2 pVL measures from the eighth month of follow-up were selected. VCY was calculated individually over the follow-up as the area under the pVL curve. Multivariate Cox models analyzed the relation between all-cause mortality and the following variables: age, sex, geographical origin, transmission group, HIV infection duration, ART-naive, pVL at baseline, time-dependent CD4 count, and VCY. Nine hundred seventy-nine patients were followed up for a median of 10 years (interquartile range: 5-11.5). At baseline, median (interquartile range) values for duration of HIV infection, pVL, and CD4 cell count were 43 (4-95) months, 4.6 (3.9-5.2) log10 copies per milliliter, and 278 (125-416) cells per cubic millimeter, respectively. At censoring date, 77 patients (8%) had died. VCY >1.4 log10 copies × yrs/mL was an independent predictor of death (hazard ratio: 2.0; 95% confidence interval: 1.2 to 3.5), which was no longer the case after adjustment for the latest pVL value [risk ratio (RR): 1.2 for 1 additional log10 copies per milliliter; 95% confidence interval: 1.1 to 1.4]. VCY was associated with mortality in HIV-infected patients under combined antiretroviral therapy but did not overweigh the predictive value of the latest pVL. VCY might be more useful as a marker of persistent viral replication than for routine clinical care.
dc.language.isoENen_US
dc.subjectviremia copy-years
dc.subject.enHIV
dc.subject.enmortality
dc.subject.enprotease inhibitor
dc.title.enViremia Copy-Years as a Predictive Marker of All-Cause Mortality in HIV-1-Infected Patients Initiating a Protease Inhibitor-Containing Antiretroviral Treatment.
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qai.0000000000000416en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
bordeaux.page204-8en_US
bordeaux.volume68en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue2en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-01115441
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2015-02-01&rft.volume=68&rft.issue=2&rft.spage=204-8&rft.epage=204-8&rft.eissn=1525-4135&rft.issn=1525-4135&rft.au=CHIROUZE,%20Catherine&JOURNOT,%20Val%C3%A9rie&LE%20MOING,%20Vincent&RAFFI,%20Fran%C3%A7ois&PIROTH,%20Lionel&rft.genre=article


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