NATI POLTRI, Simone; CALUORI, Guido; JAÏS, Pierre; COLLIN, Annabelle; POIGNARD, Clair

doi:10.1007/978-3-031-35302-4_19

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NATI POLTRI, Simone
Modélisation Mathématique pour l'Oncologie [MONC]

CALUORI, Guido
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

JAÏS, Pierre
IHU-LIRYC
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

Langue

Communication dans un congrès

Ce document a été publié dans

Lecture Notes in Computer Science, Lecture Notes in Computer Science, FIMH 2023 - 12th International Conference Functional Imaging and Modeling of the Heart, 2023-06-19, Lyon. 2023-06-16, vol. LNCS-13958, p. 184-193

Résumé en anglais

Catheter-based cardiac ablation, such as radiofrequency ablation (RFA) and pulsed electric field ablation (PFA), is the treatment of choice for atrial fibrillation (AF). However, the underlying phenomena and differences between RFA and PFA are not well understood. In this paper, we propose mathematical modeling of the cardiac electric signal of a cardiac domain containing an ablated area by RFA or PFA. Both types of ablation consist of the isolation of the pulmonary vein, but we describe them differently by using appropriate transmission conditions. More specifically, we assume that in the case of RFA, both intracellular and extracellular potentials are affected, leading to Kedem-Katchalsky type conditions at the interface. In contrast, in the case of PFA, we assume an isolation of the intracellular potential (due to the cardiomyocytes death induced by electroporation) whereas the extracellular potential is continuous. Numerical simulations in a context of AF show that PFA and RFA lead to isolation of the pulmonary vein. Our modeling also enables to propose a numerical explanation for the higher rate of fibrillation recurrence after RFA compared with PFA.< Réduire

Mots clés en anglais

Electrocardiology modeling

Radiofrequency ablation

Pulsed electric field ablation

DOI

http://dx.doi.org/10.1007/978-3-031-35302-4_19

Project ANR

Modélisation de l'électroporation irréversible pour la tachycardie ventriculaire - ANR-22-CE45-0014

Origine

Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251