A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes
| dc.rights.license | open | en_US |
| dc.contributor.author | DUPIRE, C. | |
| dc.contributor.author | CHENNELL, P. | |
| dc.contributor.author | PEREIRA, B. | |
| dc.contributor.author | COURTIOL, N. | |
| dc.contributor.author | BUJ, S. | |
| dc.contributor.author | CUEFF, R. | |
| dc.contributor.author | CRAUSTE-MANCIET, S. | |
| dc.contributor.author | SAUTOU, V. | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MORGAT, Clement | |
| dc.date.accessioned | 2023-06-28T12:44:16Z | |
| dc.date.available | 2023-06-28T12:44:16Z | |
| dc.date.issued | 2023-02-15 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183231 | |
| dc.description.abstractEn | The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [Tc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Radiopharmaceuticals | |
| dc.subject.en | Syringes | |
| dc.subject.en | Rubber | |
| dc.title.en | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes | |
| dc.title.alternative | Sci Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41598-023-29923-z | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36792806 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 2721 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | Imagerie multimodale translationnelle | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04144593 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-06-28T12:44:20Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2023-02-15&rft.volume=13&rft.issue=1&rft.spage=2721&rft.epage=2721&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=DUPIRE,%20C.&CHENNELL,%20P.&PEREIRA,%20B.&COURTIOL,%20N.&BUJ,%20S.&rft.genre=article |
