White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | PLANCHE, Vincent | |
| hal.structure.identifier | Stanford University | |
| dc.contributor.author | SU, Jason H. | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux] | |
| dc.contributor.author | MOURNET, Sandy | |
| hal.structure.identifier | University of Arizona | |
| dc.contributor.author | SARANATHAN, Manojkumar | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | DOUSSET, Vincent | |
| hal.structure.identifier | Stanford School of Medicine [Stanford] | |
| dc.contributor.author | HAN, May | |
| hal.structure.identifier | Stanford University | |
| dc.contributor.author | RUTT, Brian K. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TOURDIAS, Thomas | |
| dc.date | ||
| dc.date.accessioned | 2023-06-21T11:51:57Z | |
| dc.date.available | 2023-06-21T11:51:57Z | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182738 | |
| dc.description.abstractEn | Background: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging. Methods: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (n = 15) and matched controls (n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE. Results: WMn-MPRAGE showed more thalamic MS lesions (n = 35 in 9 out of 15 patients) than MP-FLAIR (n = 25) and standard T1 (n = 23), which was associated with significant improvement of CNR (p < 0.0001). MS patients had whole thalamus atrophy (p = 0.003) with lower volumes found for the anteroventral (p < 0.001), the pulvinar (p < 0.0001), and the habenular (p = 0.004) nuclei. Conclusion: WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy. © The Author(s), 2019. | |
| dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Thalamic nuclei | |
| dc.subject.en | Multiple sclerosis | |
| dc.subject.en | Multi-atlas segmentation | |
| dc.subject.en | White matter nulled MPRAGE | |
| dc.subject.en | Ultra-high field MRI | |
| dc.title.en | White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis | |
| dc.title.alternative | Mult Scler | en_US |
| dc.type | Document de travail - Pré-publication | en_US |
| dc.identifier.doi | 10.1177/1352458519828297 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 30730233 | en_US |
| bordeaux.page | 987-992 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.identifier.funderID | Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.spage=987-992&rft.epage=987-992&rft.au=PLANCHE,%20Vincent&SU,%20Jason%20H.&MOURNET,%20Sandy&SARANATHAN,%20Manojkumar&DOUSSET,%20Vincent&rft.genre=preprint |
