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Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction

dc.rights.licenseopenen_US
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorVANACKER, Charlotte
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorTROVA, Sara
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorSHRUTI, Sonal
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorCASONI, Filippo
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorMESSINA, Andrea
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorCROIZIER, Sophie
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorMALONE, Samuel
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorTERNIER, Gaetan
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorHANCHATE, Naresh Kumar
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorRASIKA, S.
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorBOURET, Sebastien G.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCIOFI, Philippe
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorGIACOBINI, Paolo
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorPREVOT, Vincent
dc.date.accessioned2023-06-15T13:34:35Z
dc.date.available2023-06-15T13:34:35Z
dc.date.issued2020-10-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182697
dc.description.abstractEnHypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the “master molecule” regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues, which include the semaphorins and their receptors, the neuropilins and plexins, among others. Here, we show that selectively deleting neuropilin-1 in new GnRH neurons enhances their survival and migration, resulting in excess neurons in the hypothalamus and in their unusual accumulation in the accessory olfactory bulb, as well as an acceleration of mature patterns of activity. In female mice, these alterations result in early prepubertal weight gain, premature attraction to male odors, and precocious puberty. Our findings suggest that rather than being influenced by peripheral energy state, GnRH neurons themselves, through neuropilin–semaphorin signaling, might engineer the timing of puberty by regulating peripheral adiposity and behavioral switches, thus acting as a bridge between the reproductive and metabolic axes. © 2020 The Authors
dc.description.sponsorshipLa signalisation cellulaire par les sémaphorines dans le contrôle neuroendocrinien de la reproduction - ANR-14-CE12-0015en_US
dc.description.sponsorshipVieillissement et démence: un rôle hormonal?en_US
dc.language.isoENen_US
dc.subject.enChemotropic factors
dc.subject.enEnergy homeostasis
dc.subject.enHypothalamus
dc.subject.enPuberty onset
dc.subject.enSexual behavior
dc.title.enNeuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction
dc.title.alternativeEMBO Jen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.15252/embj.2020104633en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32761635en_US
bordeaux.journalEMBO Journalen_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue19en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EMBO%20Journal&rft.date=2020-10-01&rft.volume=39&rft.issue=19&rft.au=VANACKER,%20Charlotte&TROVA,%20Sara&SHRUTI,%20Sonal&CASONI,%20Filippo&MESSINA,%20Andrea&rft.genre=article


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