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Occurrence of Side Effects in Treatment-Resistant Depression: Role of Clinical, Socio-Demographic and Environmental Characteristics

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLEVY, Anna
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorEL-HAGE, Wissam
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierLaboratoires de neurosciences intégratives et cliniques (EA 481)
dc.contributor.authorBENNABI, Djamila
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNeuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux [NPsy-Sydo]
dc.contributor.authorALLAUZE, Etienne
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alexandra
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorCAMUS, Vincent
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
dc.contributor.authorDOREY, Jean-Michel
dc.contributor.authorETAIN, Bruno
dc.contributor.authorFOND, Guillaume
dc.contributor.authorGENTY, Jean-Baptiste
dc.contributor.authorHOLTZMANN, Jerome
dc.contributor.authorHORN, Mathilde
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorMEYREL, Manon
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorNGUON, Anne-Sophie
dc.contributor.authorPETRUCCI, Jean
dc.contributor.authorREY, Romain
dc.contributor.authorRICHIERI, Raphaelle
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorVAIVA, Guillaume
dc.contributor.authorWALTER, Michel
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
dc.contributor.authorYRONDI, Antoine
dc.date.accessioned2023-06-12T09:29:25Z
dc.date.available2023-06-12T09:29:25Z
dc.date.issued2021
dc.identifier.issn1664-0640en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182644
dc.description.abstractEnIntroduction: Treatment-resistant depression (TRD) is a disabling psychiatric condition characterized by the failure of two antidepressants (ADs). Since the occurrence of side effects (SEs) appears to be one of the main determinants of early discontinuation of pharmacological treatments contributing to a pseudo-resistance, the purpose of this study was to determine the parameters associated with the occurrence of SEs under ADs in a cohort of patients with TRD.Methods: An observational, cross-sectional, multicentre study was carried out using data from the French network of Expert Centers for TRD. For the 108 patients enrolled in the study, the statistical analyses focused on the overall occurrence and on the profile of the SEs (9 categories, 32 items).Results: SEs were influenced by age and sex and were positively associated with the intensity of anxious, depressive and suicidal symptoms, a history of childhood trauma (sexual abuse, emotional abuse and neglect), and negatively associated with self-esteem, and assessment of overall functioning.Conclusion: Using variables accessible in common practice, these results fall within the dynamic of a more tailored approach to medicine that could allow, through integrated pharmacological management, the continuation of antidepressant treatments, and therefore limit the risk of therapeutic failure.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enExpert centres
dc.subject.enTreatment-resistant depression
dc.subject.enAntidepressants
dc.subject.enSide effects
dc.subject.enClinical severity
dc.subject.enChildhood trauma
dc.title.enOccurrence of Side Effects in Treatment-Resistant Depression: Role of Clinical, Socio-Demographic and Environmental Characteristics
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fpsyt.2021.795666en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34938218en_US
bordeaux.journalFrontiers in Psychiatryen_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAstraZenecaen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Psychiatry&rft.date=2021&rft.volume=12&rft.eissn=1664-0640&rft.issn=1664-0640&rft.au=LEVY,%20Anna&EL-HAGE,%20Wissam&BENNABI,%20Djamila&ALLAUZE,%20Etienne&BOUVARD,%20Alexandra&rft.genre=article


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