dc.rights.license | open | en_US |
hal.structure.identifier | Neuroscience Paris Seine [NPS] | |
dc.contributor.author | ANDRIANARIVELO, Andry | |
hal.structure.identifier | Neuroscience Paris Seine [NPS] | |
dc.contributor.author | SAINT-JOUR, Estefani | |
hal.structure.identifier | Institut de pharmacologie moléculaire et cellulaire [IPMC] | |
dc.contributor.author | POUSINHA, Paula | |
hal.structure.identifier | Institut de pharmacologie moléculaire et cellulaire [IPMC] | |
dc.contributor.author | FERNANDEZ, Sebastian P. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | PETITBON, Anna | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
hal.structure.identifier | Neuroscience Paris Seine [NPS] | |
dc.contributor.author | HECK, Nicolas | |
dc.contributor.author | ORTIZ, Vanesa | |
dc.contributor.author | ALLICHON, Marie-Charlotte | |
dc.contributor.author | KAPPÈS, Vincent | |
dc.contributor.author | BETUING, Sandrine | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | WALLE, Roman | |
dc.contributor.author | ZHU, Ying | |
dc.contributor.author | JOSEPHINE, Charlene | |
hal.structure.identifier | Commissariat à l'énergie atomique et aux énergies alternatives [CEA] | |
dc.contributor.author | BEMELMANS, Alexis-Pierre | |
dc.contributor.author | TURECKI, Gustavo | |
dc.contributor.author | MECHAWAR, Naguib | |
dc.contributor.author | JAVITCH, Jonathan A. | |
dc.contributor.author | CABOCHE, Jocelyne | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | TRIFILIEFF, Pierre | |
dc.contributor.author | BARIK, Jacques | |
dc.contributor.author | VANHOUTTE, Peter | |
dc.date.accessioned | 2023-06-09T08:20:47Z | |
dc.date.available | 2023-06-09T08:20:47Z | |
dc.date.issued | 2021-10-20 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182609 | |
dc.description.abstractEn | Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission and hijacks natural reward processing. Here, we provide evidence, from mice to humans, that an underlying mechanism relies on drug-evoked heteromerization of glutamate N-methyl-d-aspartate receptors (NMDAR) with dopamine receptor 1 (D1R) or 2 (D2R). Using temporally controlled inhibition of D1R-NMDAR heteromerization, we unraveled their selective implication in early phases of cocaine-mediated synaptic, morphological, and behavioral responses. In contrast, preventing D2R-NMDAR heteromerization blocked the persistence of these adaptations. Interfering with these heteromers spared natural reward processing. Notably, we established that D2R-NMDAR complexes exist in human samples and showed that, despite a decreased D2R protein expression in the NAc, individuals with psychostimulant use disorder display a higher proportion of D2R forming heteromers with NMDAR. These findings contribute to a better understanding of molecular mechanisms underlying addiction and uncover D2R-NMDAR heteromers as targets with potential therapeutic value. | |
dc.description.sponsorship | Contribution des astrocytes aux ondulations hippocampiques - ANR-15-CE16-0001 | en_US |
dc.description.sponsorship | Cibler les complexes formés par les récepteurs de la dopamine et du glutamate pour atténuer les pathologies liées au stress | en_US |
dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux | en_US |
dc.description.sponsorship | Contribution d'un état hypodopaminergique dorsostriatal dans le développement de l'usage compulsif d'alcool : Implication pour les mécanismes physiopathologiques de l'alcoolodépendance | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.title.en | Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1126/sciadv.abg5970 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
bordeaux.journal | Science Advances | en_US |
bordeaux.page | eabg5970 | en_US |
bordeaux.volume | 7 | en_US |
bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 43 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement | en_US |
hal.export | false | |
dc.rights.cc | CC BY-NC | en_US |
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