Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CHATAIGNER, Mathilde | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LUCAS, Celine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DI MICELI, Mathieu | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PALLET, Veronique
ORCID: 0000-0002-9078-3269 IDREF: 066841763 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.contributor.author | MEHAIGNERIE, Alexis | |
| dc.contributor.author | BOUVRET, Elodie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DINEL, Anne Laure
ORCID: 0000-0002-8668-9413 IDREF: 131872109 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| dc.date.accessioned | 2023-06-09T08:19:07Z | |
| dc.date.available | 2023-06-09T08:19:07Z | |
| dc.date.issued | 2021-11-23 | |
| dc.identifier.issn | 2296-861X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182608 | |
| dc.description.abstractEn | Brain aging is characterized by a chronic low-grade inflammation, which significantly impairs cognitive function. Microglial cells, the immunocompetent cells of the brain, present a different phenotype, switching from a homeostatic signature (M0) to a more reactive phenotype called “MGnD” (microglial neurodegenerative phenotype), leading to a high production of pro-inflammatory cytokines. Furthermore, microglial cells can be activated by age-induced gut dysbiosis through the vagus nerve or the modulation of the peripheral immune system. Nutrients, in particular n-3 long chain polyunsaturated fatty acids (LC-PUFAs) and low molecular weight peptides, display powerful immunomodulatory properties, and can thus prevent age-related cognitive decline. The objective of this study was to investigate the effects of n-3 LC-PUFAs and low molecular weight peptides contained in a marine by-product-derived hydrolysate on microglial phenotypes and intestinal permeability and their consequences on cognition in mice. We demonstrated that the hydrolysate supplementation for 8 weeks prevented short- and long-term memory decline during aging. These observations were linked to the modulation of microglial signature. Indeed, the hydrolysate supplementation promoted homeostatic microglial phenotype by increasing TGF-β1 expression and stimulated phagocytosis by increasing Clec7a expression. Moreover, the hydrolysate supplementation promoted anti-inflammatory intestinal pathway and tended to prevent intestinal permeability alteration occurring during aging. Therefore, the fish hydrolysate appears as an interesting candidate to prevent cognitive decline during aging. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | N-3 long chain PUFA | |
| dc.subject.en | Low molecular weight peptides | |
| dc.subject.en | Microglia | |
| dc.subject.en | Memory | |
| dc.subject.en | Hydrolysate | |
| dc.subject.en | Cognitive decline | |
| dc.subject.en | Aging | |
| dc.title.en | Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnut.2021.750292 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 34888336 | en_US |
| bordeaux.journal | Frontiers in nutrition | en_US |
| bordeaux.volume | 8 | en_US |
| bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20nutrition&rft.date=2021-11-23&rft.volume=8&rft.eissn=2296-861X&rft.issn=2296-861X&rft.au=CHATAIGNER,%20Mathilde&LUCAS,%20Celine&DI%20MICELI,%20Mathieu&PALLET,%20Veronique&LAYE,%20Sophie&rft.genre=article |
