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Characterization of depressed bipolar patients with current suicidal ideation

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorNOBILE, Benedicte
dc.contributor.authorDUBOIS, Jonathan
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
IDREF: 069471851
hal.structure.identifierThe Princess Grace Hospital
dc.contributor.authorAUBIN, Valerie
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierThe Princess Grace Hospital
dc.contributor.authorLOFTUS, Josephine
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorBELLIVIER, Frank
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGARD, Sebastien
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'Investigation Clinique de Besançon [Inserm CIC 1431]
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorROUX, Paul
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorETAIN, Bruno
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorOLIE, Emilie
dc.date.accessioned2023-06-08T13:53:26Z
dc.date.available2023-06-08T13:53:26Z
dc.date.issued2021-03
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182539
dc.description.abstractEnObjective: Bipolar disorder is one of the most frequent psychiatric disorders among suicidal patients. A large part of patients with bipolar disorder (30-50%) will attempt suicide. Suicidal ideation being a major risk factor of suicidal act, it is crucial to better characterize patients with suicidal bipolar depression (i.e. depression with current suicidal ideation). The aim of this study was to characterize suicidal bipolar depressed patients in comparison with non-suicidal depressed patients in terms of clinical characteristics, evolution of depression and suicidal ideation course over time, and risk of suicide attempt during follow-up. Methods: Among patients with bipolar disorder recruited from the network of FondaMental expert centres for bipolar disorder between 2009 and 2017, we selected patients with at least mild depression (Montgomery-angstrom sberg Depression Rating Scale total score >11) and without current manic symptomatology (Young Mania Rating Scale total score <7) at baseline (N = 938). Suicidal depression was defined by a baseline score > 2 for item 12 of the Quick Inventory of Depressive Symptomatology-Self Report (N = 271, 28.9%). Non-suicidal depression was defined by a baseline item 12 of the Quick Inventory of Depressive Symptomatology-Self Report score <2 (N = 667, 71.1%). A subsample of about 300 patients (with or without suicidal ideation at baseline) was followed up for 2 years. Results: Baseline clinical features (e.g. depression severity, childhood trauma, global functioning) were more severe in patients with than without suicidal depression. Suicidal patients tended to remain more suicidal throughout the follow-up than patients without suicidal ideation at baseline (3.4-fold higher risk of persistent suicidal ideation at the 2-year visit despite an improvement in depressive symptomatology). Conclusions: Depressed bipolar disorder patients reporting suicidal ideation had more severe clinical features at baseline and were more prone to report persistent suicidal ideation during the follow-up, independently of thymic state. Clinicians should closely monitor this subgroup of patients.
dc.language.isoENen_US
dc.title.enCharacterization of depressed bipolar patients with current suicidal ideation
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/0004867420963744en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33043675en_US
bordeaux.journalAustralian and New Zealand Journal of Psychiatryen_US
bordeaux.page289en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Australian%20and%20New%20Zealand%20Journal%20of%20Psychiatry&amp;rft.date=2021-03&amp;rft.volume=55&amp;rft.issue=3&amp;rft.spage=289&amp;rft.epage=289&amp;rft.au=NOBILE,%20Benedicte&amp;DUBOIS,%20Jonathan&amp;AOUIZERATE,%20Bruno&amp;AUBIN,%20Valerie&amp;LOFTUS,%20Josephine&amp;rft.genre=article


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