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Confirmations, advances and recommendations for the daily care of schizophrenia based on the French national FACE-SZ cohort

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorFOND, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorSCHURHOFF, Franck
hal.structure.identifierNeuropsychologie Cognitive et Physiopathologie de la Schizophrénie [NCPS]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBERNA, Fabrice
dc.contributor.authorANDRE, M.
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCAPDEVIELLE, Delphine
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNeuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux [NPsy-Sydo]
dc.contributor.authorCHEREAU, Isabelle
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorD′AMATO, Thierry
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorDUBREUCQ, J.
dc.contributor.authorFAGET, C.
dc.contributor.authorLANCON, C.
dc.contributor.authorLEIGNIER, S.
dc.contributor.authorMALLET, J.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, C.
dc.contributor.authorPIGNON, B.
dc.contributor.authorREY, R.
dc.contributor.authorSZOKE, A.
dc.contributor.authorURBACH, M.
dc.contributor.authorVIDAILHET, P.
dc.contributor.authorLEBOYER, M.
dc.contributor.authorBOYER, L.
dc.contributor.authorLLORCA, P. M.
dc.date.accessioned2023-06-05T14:25:22Z
dc.date.available2023-06-05T14:25:22Z
dc.date.issued2020-07-13
dc.identifier.issn0278-5846en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182487
dc.description.abstractEnBackground The National FondaMental Centers of Expertise (FACE) for Schizophrenia (SZ) have been created to shorten the gap between research and clinical practice. Objectives To synthetize in a review the 10-year findings issued from the FACE-SZ cohort analyses. Methods More than 1000 patients were evaluated in 10 expert centers since 2010 with a 2-day long comprehensive standardized battery including neuropsychological testes and physical health assessment and followed-up for 3 years. Results 1. The phase 0 cross-sectional analyses have confirmed well-known data: over-prescription of first-generation antipsychotics, antipsychotic polytherapy and long-term benzodiazepine and under-prescription of clozapine, 13% of drug-induced parkinsonism, 18% of akathisia, a mean duration of untreated psychosis of 18 months, one third of poorly-adherent patients, 24% of metabolic syndrome and 52% of current tobacco smokers with poor care for physical illnesses; a yearly mean financial cost of 15,000 euro/patient. 2. FACE-SZ also yielded additional data in insufficiently explored area: a half of major depression issues (among them one third of undiagnosed major depression and 44% of treated patients with unremitted depression), major depression having a strong impact on Quality of Life independently of negative symptoms, 22% of moderated to severe untreated physical pain. 3. FACE-SZ has explored emerging fields of research, including development of 4 stages- model of schizophrenia, chronic low-grade peripheral inflammation, latent Toxoplasma infection, hypovitaminosis D, and a model for relapse prediction at 2 years. Discussion The associated factors and implications for public health programs were discussed. Based on the FACE-SZ findings and literature, the FACE-SZ group has yielded recommendations to improve daily care for schizophrenia and for future research.
dc.language.isoENen_US
dc.subject.enSchizophrenia
dc.subject.enCohort
dc.subject.enFACE-SZ
dc.subject.enDaily practice
dc.subject.enRecommendations
dc.title.enConfirmations, advances and recommendations for the daily care of schizophrenia based on the French national FACE-SZ cohort
dc.title.alternativeProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.pnpbp.2020.109927en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
bordeaux.page109927en_US
bordeaux.volume101en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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