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Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy

dc.rights.licenseopenen_US
dc.contributor.authorCOUFFIGNAL, Camille
dc.contributor.authorKOLTA, Sami
dc.contributor.authorFLAMANT, Martin
hal.structure.identifierService des Maladies Infectieuses et Tropicales A [Bordeaux]
dc.contributor.authorCAZANAVE, Charles
dc.contributor.authorHAYMANN, Jean-Philippe
dc.contributor.authorMENTRE, France
dc.contributor.authorDUVAL, Xavier
dc.contributor.authorLEPORT, Catherine
dc.contributor.authorRAFFI, Francois
dc.contributor.authorCHÊNE, G.
dc.contributor.authorSALAMON, R.
dc.contributor.authorMOATTI, J.
dc.contributor.authorPIERRET, J.
dc.contributor.authorSPIRE, B.
dc.contributor.authorBRUN-VÉZINET, F.
dc.contributor.authorFLEURY, H.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMASQUELIER, B.
dc.contributor.authorPEYTAVIN, G.
dc.contributor.authorGARRAFFO, R.
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorDELLAMONICA, P.
dc.contributor.authorKATLAMA, C.
dc.contributor.authorMEYER, L.
dc.contributor.authorSALMON, D.
dc.contributor.authorCUZIN, L.
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorDUPON, M.
dc.contributor.authorLE MOING, V.
dc.contributor.authorMARCHOU, B.
dc.contributor.authorMAY, T.
dc.contributor.authorMORLAT, P.
dc.contributor.authorRABAUD, C.
dc.contributor.authorWALDNER-COMBERNOUX, A.
dc.contributor.authorHARDEL, L.
dc.contributor.authorREBOUD, P.
dc.contributor.authorCOUFFIN-CADIERGUES, S.
dc.contributor.authorMARCHAND, L.
dc.contributor.authorASSUIED, A.
dc.contributor.authorCARRIERI, P.
dc.contributor.authorHABAK, S.
dc.contributor.authorCOUTURIER, F.
dc.contributor.authorJADAND, C.
dc.contributor.authorPERRIER, A.
dc.contributor.authorPRÉAU, M.
dc.contributor.authorPROTOPOPESCU, C.
dc.contributor.authorSCHMIT, J.L.
dc.contributor.authorCHENNEBAULT, J.M.
dc.contributor.authorFALLER, J.P.
dc.contributor.authorMAGY-BERTRAND, N.
dc.contributor.authorCHIROUZE, C.
dc.contributor.authorHUMBERT, P.
dc.contributor.authorNEAU, D.
dc.contributor.authorGRANIER, P.
dc.contributor.authorANSART, S.
dc.contributor.authorVERDON, R.
dc.contributor.authorMERRIEN, D.
dc.contributor.authorCHEVOJON, P.
dc.contributor.authorSOBEL, A.
dc.contributor.authorLEVY, Y.
dc.contributor.authorPIROTH, L.
dc.contributor.authorPERRONNE, C.
dc.contributor.authorFROGUEL, E.
dc.contributor.authorCECCALDI, J.
dc.contributor.authorCHIDIAC, C.
dc.contributor.authorGRÉGOIRE, V.
dc.contributor.authorREYNES, J.
dc.contributor.authorFUZIBET, J.
dc.contributor.authorARSAC, P.
dc.contributor.authorBOUVET, E.
dc.contributor.authorBRICAIRE, F.
dc.contributor.authorMONSONEGO, J.
dc.contributor.authorGIRARD, P.M.
dc.contributor.authorGUILLEVIN, L.
dc.contributor.authorHERSON, S.
dc.contributor.authorMOLINA, J.M.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorSAIN, O.
dc.contributor.authorSELLIER, P.
dc.contributor.authorROBLOT, F.
dc.contributor.authorBANI-SADR, F.
dc.contributor.authorMICHELET, C.
dc.contributor.authorLUCHT, F.
dc.contributor.authorDEBORD, C.
dc.contributor.authorMARTIN, T.
dc.contributor.authorDE JAUREGUIBERRY, J.P.
dc.contributor.authorBERNARD, L.
dc.date.accessioned2023-06-01T16:05:38Z
dc.date.available2023-06-01T16:05:38Z
dc.date.issued2020-02-24
dc.identifier.issn0889-2229en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182406
dc.description.abstractEnWe assessed bone mineral density (BMD) in a cohort of human immunodeficiency virus (HIV)-positive patients after a median of 11 years of combination antiretroviral therapy (cART) and evaluated the respective role of HIV infection and antiretroviral drugs (ARVs). A cross-sectional study of 162 participants (131 male) from the ANRS-C08 cohort was performed with bone dual-energy X-ray absorptiometry (DXA) scans and renal assessment. The window of exposure to ARVs was defined as an exposure of more than six cumulative months during the last 3 years before the DXA evaluation to account for a cumulative exposure that could affect bone remodeling. The association with low BMD (Z-score < -2) was assessed by a multiple logistic regression model. The study population was 50 years (median), hepatitis C virus (HCV) (18%), and hepatitis B virus (HBV) (8%) coinfection with HIV-RNA <50 c/mL in 89%, median CD4 of 619/mm3. Prevalence of low BMD was 18% in males and 6% in females. The factors associated with a Z-score < -2 in males were uric acid renal loss [adjusted odds ratio (aOR): 6.1; 95% confidence interval (CI): 1.2-31.5; p = .03], HCV coinfection (aOR: 4.0; 95% CI: 1.3-12.2; p = .02), and less frequent window of exposure to nevirapine (NVP) (aOR: 0.1; 95% CI: 0.02-0.6; p = .01). For the full study sample, there was a strong positive association between duration of exposure to NVP and lumbar spine Z-score (p = .004). HIV-positive patients exposed to long-term cART have a high incidence of low BMD. Tenofovir disoproxil fumarate and ritonavir-boosted protease inhibitors did not seem to be associated with increased risk of low BMD, whereas NVP exposure appeared to have an independent positive association.
dc.language.isoENen_US
dc.subject.enHIV
dc.subject.enbone mineral density
dc.subject.ennevirapine
dc.title.enNevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy
dc.typeArticle de revueen_US
dc.identifier.doi10.1089/AID.2019.0229en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAIDS Research and Human Retrovirusesen_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02548927
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=AIDS%20Research%20and%20Human%20Retroviruses&amp;rft.date=2020-02-24&amp;rft.eissn=0889-2229&amp;rft.issn=0889-2229&amp;rft.au=COUFFIGNAL,%20Camille&amp;KOLTA,%20Sami&amp;FLAMANT,%20Martin&amp;CAZANAVE,%20Charles&amp;HAYMANN,%20Jean-Philippe&amp;rft.genre=article


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