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Childhood maltreatment and clinical severity of treatment-resistant depression in a French cohort of outpatients (FACE-DR): One-year follow-up

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorYRONDI, Antoine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBENNABI, Djamila
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorRICHIERI, Raphaelle
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorD'AMATO, Thierry
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELLIVIER, Frank
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBOUGEROL, Thierry
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHORN, Mathilde
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCAMUS, Vincent
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDOUMY, Olivier
dc.contributor.authorGENTY, Jean B.
dc.contributor.authorHOLTZMANN, Jerome
dc.contributor.authorLANCON, Christophe
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorLLORCA, Pierre M.
dc.contributor.authorMARUANI, Julia
dc.contributor.authorMOIRAND, Remi
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorSCHMITT, Laurent
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorVAIVA, Guillame
dc.contributor.authorWALTER, Michel
dc.contributor.authorPETRUCCI, Jean
dc.contributor.authorCOLLABORATORS, FondaMental Advanced Centers Of Expertise In Resistant Depression (FACE-DR)
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorEL-HAGE, Wissam
dc.date.accessioned2023-05-31T14:27:17Z
dc.date.available2023-05-31T14:27:17Z
dc.date.issued2020
dc.identifier.issn1520-6394en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182393
dc.description.abstractEnBackground Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20–30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up. Methods Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery–Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire (CTQ). Results In total, 256 patients filled in the CTQ at baseline between 2012 and 2019. At baseline, the MADRS score was associated with CTQ score (β = .185; p = .004). QIDS was also associated with CTQ scores (β = .27; p < .001). Regarding the different subtypes of childhood maltreatment, MADRS was associated with physical (β = .21; p = .005) and sexual abuse (β = .22; p = .002), while QIDS with physical abuse (β = .304; p < .001) and physical neglect (β = .254; p < .001). However, we did not find any significant association focusing on the other types of traumas. During a 1-year follow-up focusing on remission, CTQ scores (baseline) were less important in remittent patients [n = 38; CTQ score = 39.26 (9.68)] than in nonremittent ones [n = 92; CTQ score = 46.02 (17.53)] (p = .027). There was no significant difference among remitters and nonremitters based on trauma subtypes. At baseline, CTQ scores had a significant influence on remission at 1 year (χ2(1) = 5.57; p < .05). We lost this influence adding MADRS scores at baseline in the model (p = .063). Conclusion We highlighted a significant association between the severity of depressive disorders and childhood maltreatment in the TRD population. Information about a history of childhood maltreatment helps in identifying individuals who could be less likely to go into remission after treatment.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.subject.enantidepressant response
dc.subject.enchildhood abuse
dc.subject.enchildhood neglect
dc.subject.enchildhood trauma
dc.subject.endepressive disorders
dc.subject.entreatment-resistant depression
dc.title.enChildhood maltreatment and clinical severity of treatment-resistant depression in a French cohort of outpatients (FACE-DR): One-year follow-up
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/da.22997en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31999402en_US
bordeaux.journalDepression and Anxietyen_US
bordeaux.page365-374en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Depression%20and%20Anxiety&amp;rft.date=2020&amp;rft.volume=37&amp;rft.issue=4&amp;rft.spage=365-374&amp;rft.epage=365-374&amp;rft.eissn=1520-6394&amp;rft.issn=1520-6394&amp;rft.au=YRONDI,%20Antoine&amp;AOUIZERATE,%20Bruno&amp;BENNABI,%20Djamila&amp;RICHIERI,%20Raphaelle&amp;D'AMATO,%20Thierry&amp;rft.genre=article


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