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dc.rights.licenseopenen_US
dc.contributor.authorKHAZEN, Tala
dc.contributor.authorNARATTIL, Nisha Rajan
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorMAROUN, Mouna
dc.date.accessioned2023-05-31T09:35:52Z
dc.date.available2023-05-31T09:35:52Z
dc.date.issued2023-04-01
dc.identifier.issn1047-3211en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182383
dc.description.abstractEnThe hippocampus undergoes maturation during juvenility, a period of increased vulnerability to environmental challenges. We recently found that acute high-fat diet (HFD) impaired hippocampal long-term potentiation (LTP) and hippocampal-dependent spatial memory. We also recently reported that similar HFD exposure affected prefrontal plasticity and social memory through decreased oxytocin levels in the prefrontal cortex. In the present study, we therefore evaluated whether hippocampal oxytocin levels are also affected by juvenile HFD and could mediate deficits of hippocampal LTP and spatial memory. We found that postweaning HFD decreased oxytocin levels in the CA1 of the dorsal hippocampus. Interestingly, systemic injection of high, but not low, dose of oxytocin rescued HFD-induced LTP impairment in CA1. Moreover, deficits in long-term object location memory (OLM) were prevented by systemic injection of both high and low dose of oxytocin as well as by intra-CA1 infusion of oxytocin receptor agonist. Finally, we found that blocking oxytocin receptors in CA1 impaired long-term OLM in control-fed juvenile rats. These results suggest that acute HFD intake lowers oxytocin levels in the CA1 that lead to CA1 plasticity impairment and spatial memory deficits in juveniles. Further, these results provide the first evidence for the regulatory role of oxytocin in spatial memory.
dc.language.isoENen_US
dc.subject.enHippocampus
dc.subject.enJuvenile
dc.subject.enHigh-fat diet
dc.subject.enOxytocin
dc.subject.enLTP
dc.title.enHippocampal oxytocin is involved in spatial memory and synaptic plasticity deficits following acute high-fat diet intake in juvenile rats
dc.title.alternativeCerebral Cortexen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhac317en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35989314en_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page3934-3943en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2023-04-01&rft.volume=33&rft.issue=7&rft.spage=3934-3943&rft.epage=3934-3943&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=KHAZEN,%20Tala&NARATTIL,%20Nisha%20Rajan&FERREIRA,%20Guillaume&MAROUN,%20Mouna&rft.genre=article


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