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Evolution and characteristics of the use of valproate in women of childbearing age with bipolar disorder: Results from the FACE-BD cohort

dc.rights.licenseopenen_US
hal.structure.identifierCHU Clermont-Ferrand
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSAMALIN, Ludovic
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorOLIE, Emilie
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierGroupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
dc.contributor.authorETAIN, Bruno
hal.structure.identifierGHU Paris Psychiatrie et Neurosciences
dc.contributor.authorHENRY, Chantal
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPELLETIER, Amandine
dc.contributor.authorPOINSO, F.
dc.contributor.authorENCELY, L.
dc.contributor.authorMAZER, N.
dc.contributor.authorROUX, P.
dc.contributor.authorLOFTUS, J
dc.contributor.authorGARD, S.
dc.contributor.authorBENNABI, D.
dc.contributor.authorPOLOSAN, M.
dc.contributor.authorSCHWITZER, T.
dc.contributor.authorAUBIN, V.
dc.contributor.authorSCHWAN, R.
dc.contributor.authorPASSERIEUX, C.
dc.contributor.authorBOUGEROL, T.
dc.contributor.authorDUBERTRET, C.
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorHAFFEN, E.
dc.contributor.authorCOURTET, P.
dc.contributor.authorBELLIVIER, F.
dc.contributor.authorLEBOYER, M.
dc.contributor.authorLLORCA, P. M.
dc.contributor.authorBELZEAUX, R.
dc.date.accessioned2023-05-31T09:22:00Z
dc.date.available2023-05-31T09:22:00Z
dc.date.issued2020-11-01
dc.identifier.issn0165-0327en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182382
dc.description.abstractEnBackground Valproate is associated with teratogenic and neurodevelopmental effects. Several agencies have restricted the conditions of its prescription in bipolar disorders (BD). We aimed to assess the evolution of valproate prescription and the clinical profile of BD women of childbearing age receiving valproate. Methods Based on a large national cohort, we included all BD women 16–50 years old. Sociodemographic, clinical and pharmacological data were recorded. Logistic regression analyses were used to describe variables associated with valproate prescription. Results Of the 1018 included women 16–50 years old, 26.9% were treated with valproate with a mean daily dosage of 968 mg. The prevalence of BD women using valproate was 32.6% before May 2015 and 17.3% after May 2015 (p<0.001), the date of French regulatory publication of restriction of valproate prescription. The multivariate analysis revealed that the inclusion period after May 2015 (OR=0.54, CI 95% 0.37–0.78, p=0.001), the age lower than 40 years (OR=0.65, CI 95% 0.43–0.98, p=0.040) and the number of lifetime mood episodes (OR=0.98, CI 95% 0.95–0.99, p=0.040) were the variables negatively associated with the use of valproate. Limitations Study could be underpowered to determine a clinical profile associated with valproate prescription. Conclusions The regulatory change in BD women of childbearing age had a significant impact on valproate prescription, even if the prescription rate remains high. Important efforts are needed to help clinicians and patients to improve quality of care in BD women of childbearing age.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enAnticonvulsant
dc.subject.enBipolar disorder
dc.subject.enPregnancy
dc.subject.enValproate
dc.subject.enWomen of childbearing age
dc.title.enEvolution and characteristics of the use of valproate in women of childbearing age with bipolar disorder: Results from the FACE-BD cohort
dc.title.alternativeJournal of Affective Disordersen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2020.07.078en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32745833en_US
bordeaux.journalJournal of affective disordersen_US
bordeaux.page963-969en_US
bordeaux.volume276en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20affective%20disorders&amp;rft.date=2020-11-01&amp;rft.volume=276&amp;rft.spage=963-969&amp;rft.epage=963-969&amp;rft.eissn=0165-0327&amp;rft.issn=0165-0327&amp;rft.au=SAMALIN,%20Ludovic&amp;GODIN,%20Ophelia&amp;OLIE,%20Emilie&amp;ETAIN,%20Bruno&amp;HENRY,%20Chantal&amp;rft.genre=article


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