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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorGOMBEAU, K.
dc.contributor.authorBONZOM, J.M.
dc.contributor.authorCAVALIÉ, I.
dc.contributor.authorCAMILLERI, V.
dc.contributor.authorORJOLLET, D.
dc.contributor.authorDUBOURG, N.
dc.contributor.authorBEAUGELIN-SEILLERS, K.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBOURDINEAUD, J.P.
dc.contributor.authorLENGAGNE, Thierry
dc.contributor.authorARMANT, O.
dc.contributor.authorRAVANAT, J.L.
dc.contributor.authorADAM-GUILLERMIN, C.
dc.date.accessioned2023-05-31T08:05:46Z
dc.date.available2023-05-31T08:05:46Z
dc.date.issued2020-12
dc.identifier.issn0265-931Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182381
dc.description.abstractEnThe long-term consequences of the nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) that occurred on March 2011, have been scarcely studied on wildlife. We sampled Japanese tree frogs (Dryophytes japonicus), in a 50-km area around the FDNPP to test for an increase of DNA damages and variation of DNA methylation level. The ambient dose rate ranged between 0.4 and 2.8 µGy h-1 and the total estimated dose rate absorbed by frogs ranged between 0.4 and 4.9 µGy h-1. Frogs from contaminated sites exhibited a dose dependent increase of global genomic DNA methylation level (5-mdC and 5-hmdC) and of mitochondrial DNA damages. Such DNA damages may indicate a genomic instability, which may induce physiological adaptations governed by DNA methylation changes. This study stresses the need for biological data combining targeted molecular methods and classic ecotoxicology, in order to better understand the impacts on wildlife of long term exposure to low ionizing radiation levels.
dc.language.isoENen_US
dc.subject.enJapanese tree frog-Dryophytes japonicus
dc.subject.enFukushima
dc.subject.enDNA methylation
dc.subject.enmitochondrial DNA damage
dc.subject.enionizing radiation
dc.title.enDose-dependent genomic DNA hypermethylation and mitochondrial DNA damage in Japanese tree frogs sampled in the Fukushima Daiichi area
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jenvrad.2020.106429en_US
dc.subject.halSciences de l'environnement/Biodiversité et Ecologieen_US
bordeaux.journalJournal of Environmental Radioactivityen_US
bordeaux.page106429en_US
bordeaux.volume225en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03095034
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Environmental%20Radioactivity&rft.date=2020-12&rft.volume=225&rft.spage=106429&rft.epage=106429&rft.eissn=0265-931X&rft.issn=0265-931X&rft.au=GOMBEAU,%20K.&BONZOM,%20J.M.&CAVALI%C3%89,%20I.&CAMILLERI,%20V.&ORJOLLET,%20D.&rft.genre=article


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