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dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBACCOUCH, Rim
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRASCOL, Estelle
IDREF: 183665864
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSTOKLOSA, Kaja
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorALVES, Isabel D.
dc.date.accessioned2023-05-22T14:21:48Z
dc.date.available2023-05-22T14:21:48Z
dc.date.issued2022-06-01
dc.identifier.issn0301-4622en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182239
dc.description.abstractEnG protein coupled receptors (GPCRs) are a class of membrane proteins that sense extracellular signals ranging from light to odorants and small molecules and activate intracellular signaling pathways that control important physiological responses. Being composed of 7 transmembrane helices linked by extracellular and intracellular loops, the great majority of the sequence of these receptors is embedded in the lipid membrane. Therefore, it is expected GPCR structure and function to be impacted by the surrounding lipid environment and the lipid membrane physico-chemical and mechanical properties. A large number of examples from the literature is provided to highlight the role of the lipid nature (lipid headgroup, membrane polyunsaturation and cholesterol) and membrane physical and mechanical properties (curvature elastic stress, membrane thickness and hydrophobic mismatch, fluidity) in the activity of different GPCRs. In addition, lipids are important co-factors being identified in very specific locations in several GPCR structures. GPCRs and G proteins can also be lipid post-translationally modified and such events can significantly impact membrane binding, trafficking and signaling. These aspects are all treated in this review. Understanding how the lipid can modulate GPCR activity is important not only from a fundamental point of view but also due to the fact that certain pathologies, where GPCRs are central targets, have been associated with important lipid imbalance. Establishing a link between the lipid pathological imbalance and the receptor functioning in such environment is thus essential as it can open avenues to potentially innovative therapeutic strategies.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enG protein coupled receptors
dc.subject.enLipids
dc.subject.enReceptor activation and signaling
dc.subject.enLipid membrane physico-chemical properties
dc.title.enThe role of the lipid environment in the activity of G protein coupled receptors
dc.title.alternativeBiophysical Chemistryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bpc.2022.106794en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalBiophysical Chemistryen_US
bordeaux.volume285en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biophysical%20Chemistry&rft.date=2022-06-01&rft.volume=285&rft.eissn=0301-4622&rft.issn=0301-4622&rft.au=BACCOUCH,%20Rim&RASCOL,%20Estelle&STOKLOSA,%20Kaja&ALVES,%20Isabel%20D.&rft.genre=article


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