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Handedness as a neurodevelopmental marker in schizophrenia: Results from the FACE-SZ cohort

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorMALLET, Jasmina
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLE STRAT, Yann
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorMAZER, Nicolas
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierFédération de Médecine Translationnelle de Strasbourg [FMTS]
dc.contributor.authorBERNA, Fabrice
dc.contributor.authorBOYER, L.
dc.contributor.authorCAPDEVIELLE, D.
dc.contributor.authorCLAUSS, J.
hal.structure.identifierCHU Clermont-Ferrand
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCHEREAU, Isabelle
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorD'AMATO, Thierry
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDUBREUCQ, Julien
dc.contributor.authorLEIGNER, S.
dc.contributor.authorLLORCA, P.-M.
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, C.
dc.contributor.authorREY, R.
dc.contributor.authorPIGNON, B.
dc.contributor.authorURBACH, M.
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSCHURHOFF, Franck
dc.contributor.authorFOND, G.
dc.contributor.authorDUBERTRET, C.
dc.contributor.authorTHE, FACE-SZ, (FondaMental, Academic, Center, Of, Expertise, For, Schizophrenia, Group)
dc.date.accessioned2023-05-22T13:32:17Z
dc.date.available2023-05-22T13:32:17Z
dc.date.issued2022
dc.identifier.issn1562-2975en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182228
dc.description.abstractEnObjectives: High rates of non-right-handedness (NRH) including mixed-handedness have been reported in neurodevelopmental disorders. In schizophrenia (SZ), atypical handedness has been inconsistently related to impaired features. We aimed to determine whether SZ subjects with NRH and mixed-handedness had poorer clinical and cognitive outcomes compared to their counterparts. Methods: 667 participants were tested with a battery of neuropsychological tests, and assessed for laterality using the Edinburg Handedness Inventory. Clinical symptomatology was assessed. Learning disorders and obstetrical complications were recorded. Biological parameters were explored. Results: The prevalence of NRH and mixed-handedness was high (respectively, 42.4% and 34.1%). In the multivariable analyses, NRH was associated with cannabis use disorder (p = 0.045). Mixed-handedness was associated with positive symptoms (p = 0.041), current depressive disorder (p = 0.005)), current cannabis use (p = 0.024) and less akathisia (p = 0.019). A history of learning disorder was associated with NRH. No association was found with cognition, trauma history, obstetrical complications, psychotic symptoms, peripheral inflammation. Conclusions: Non-right and mixed-handedness are very high in patients with SZ, possibly reflecting a neurodevelopmental origin. NRH is associated with learning disorders and cannabis use. Mixed-handedness is associated with positive symptoms, current depressive disorder, cannabis use and less akathisia. However, this study did not confirm greater cognitive impairment in these patients. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enSchizophrenia
dc.subject.enPsychosis
dc.subject.enCognition
dc.subject.enNeurodevelopment
dc.subject.enHandedness
dc.title.enHandedness as a neurodevelopmental marker in schizophrenia: Results from the FACE-SZ cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/15622975.2021.2013094en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34918618en_US
bordeaux.journalWorld Journal of Biological Psychiatryen_US
bordeaux.page525-536en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
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dc.rights.ccPas de Licence CCen_US
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