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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSANZ ARIGITA, Ernesto
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorDAVIAUX, Yannick
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorJOLIOT, Marc
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDILHARREGUY, Bixente
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorMICOULAUD FRANCHI, Jean Arthur
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorBIOULAC, Stephanie
ORCID: 0000-0003-2618-4234
IDREF: 059280824
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorTAILLARD, Jacques
ORCID: 0000-0001-9067-8189
IDREF: 229930786
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorPHILIP, Pierre
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorALTENA, Ellemarije
dc.date.accessioned2023-05-17T09:53:21Z
dc.date.available2023-05-17T09:53:21Z
dc.date.issued2021-09-13
dc.identifier.issn1550-9109en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182194
dc.description.abstractEnEmotional reactivity to negative stimuli has been investigated in insomnia, but little is known about emotional reactivity to positive stimuli and its neural representation. We used 3 Tesla functional magnetic resonance imaging (fMRI) to determine neural reactivity during the presentation of standardized short, 10- to 40-seconds, humorous films in patients with insomnia (n = 20, 18 females, aged 27.7 +/- 8.6 years) and age-matched individuals without insomnia (n = 20, 19 females, aged 26.7 +/- 7.0 years) and assessed humor ratings through a visual analog scale. Seed-based functional connectivity was analyzed for the left and right amygdalas (lAMYG and rAMYG, respectively) networks: group-level mixed-effects analysis (FLAME; FMRIB Software Library [FSL]) was used to compare amygdala connectivity maps between groups. fMRI seed-based analysis of the amygdala revealed stronger neural reactivity in patients with insomnia than in controls in several brain network clusters within the reward brain network, without humor rating differences between groups (p = 0.6). For lAMYG connectivity, cluster maxima were in the left caudate (Z = 3.88), left putamen (Z = 3.79), and left anterior cingulate gyrus (Z = 4.11), whereas for rAMYG connectivity, cluster maxima were in the left caudate (Z = 4.05), right insula (Z = 3.83), and left anterior cingulate gyrus (Z = 4.29). Cluster maxima of the rAMYG network were correlated with hyperarousal scores in patients with insomnia only. The presentation of humorous films leads to increased brain activity in the neural reward network for patients with insomnia compared with controls, related to hyperarousal features in patients with insomnia, in the absence of humor rating group differences. These novel findings may benefit insomnia treatment interventions. The Sleepless Brain: Neuroimaging Support for a Differential Diagnosis of Insomnia (SOMNET). ClinicalTrials.gov identifier: NCT02821234; https://clinicaltrials.gov/ct2/show/NCT02821234.
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.subject.enAdult
dc.subject.enAmygdala
dc.subject.enBrain
dc.subject.enBrain Mapping
dc.subject.enFemale
dc.subject.enGyrus Cinguli
dc.subject.enHumans
dc.subject.enMagnetic Resonance Imaging
dc.subject.enSleep Initiation and Maintenance Disorders
dc.subject.enYoung Adult
dc.title.enBrain reactivity to humorous films is affected by insomnia.
dc.title.alternativeSleepen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/sleep/zsab081en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentaleen_US
dc.identifier.pubmed33772591en_US
bordeaux.journalSLEEPen_US
bordeaux.volume44en_US
bordeaux.hal.laboratoriesSANPSY (Sommeil, Addiction, Neuropsychiatrie) - UMR 6033en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04099940
hal.version1
hal.date.transferred2023-05-17T09:53:24Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=SLEEP&rft.date=2021-09-13&rft.volume=44&rft.issue=9&rft.eissn=1550-9109&rft.issn=1550-9109&rft.au=SANZ%20ARIGITA,%20Ernesto&DAVIAUX,%20Yannick&JOLIOT,%20Marc&DILHARREGUY,%20Bixente&MICOULAUD%20FRANCHI,%20Jean%20Arthur&rft.genre=article


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