dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DUPERRON, Marie-Gabrielle | |
dc.contributor.author | KNOL, Maria J. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | LE GRAND, Quentin | |
dc.contributor.author | EVANS, Tavia E. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | MISHRA, Aniket | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TSUCHIDA, Ami | |
dc.contributor.author | ROSHCHUPKIN, Gennady | |
dc.contributor.author | KONUMA, Takahiro | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TREGOUET, David-Alexandre | |
dc.contributor.author | ROMERO, Jose Rafael | |
dc.contributor.author | FRENZEL, Stefan | |
dc.contributor.author | LUCIANO, Michelle | |
dc.contributor.author | HOFER, Edith | |
dc.contributor.author | BOURGEY, Mathieu | |
dc.contributor.author | DUEKER, Nicole D. | |
dc.contributor.author | DELGADO, Pilar | |
dc.contributor.author | HILAL, Saima | |
dc.contributor.author | TANKARD, Rick M. | |
dc.contributor.author | DUBOST, Florian | |
dc.contributor.author | SHIN, Jean | |
dc.contributor.author | SABA, Yasaman | |
dc.contributor.author | ARMSTRONG, Nicola J. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | BORDES, Constance | |
dc.contributor.author | BASTIN, Mark E. | |
dc.contributor.author | BEISER, Alexa | |
dc.contributor.author | BRODATY, Henry | |
dc.contributor.author | BULOW, Robin | |
dc.contributor.author | CARRERA, Caty | |
dc.contributor.author | CHEN, Christopher | |
dc.contributor.author | CHENG, Ching-Yu | |
dc.contributor.author | DEARY, Ian J. | |
dc.contributor.author | GAMPAWAR, Piyush G. | |
dc.contributor.author | HIMALI, Jayandra J. | |
dc.contributor.author | JIANG, Jiyang | |
dc.contributor.author | KAWAGUCHI, Takahisa | |
dc.contributor.author | LI, Shuo | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | MACALLI, Melissa | |
dc.contributor.author | MARQUIS, Pascale | |
dc.contributor.author | MORRIS, Zoe | |
dc.contributor.author | MUNOZ MANIEGA, Susana | |
dc.contributor.author | MIYAMOTO, Susumu | |
dc.contributor.author | OKAWA, Masakazu | |
dc.contributor.author | PARADISE, Matthew | |
dc.contributor.author | PARVA, Pedram | |
dc.contributor.author | RUNDEK, Tatjana | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SARGURUPREMRAJ, Muralidharan | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SCHILLING, Sabrina | |
dc.contributor.author | SETOH, Kazuya | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SOUKARIEH, Omar | |
dc.contributor.author | TABARA, Yasuharu | |
dc.contributor.author | TEUMER, Alexander | |
dc.contributor.author | THALAMUTHU, Anbupalam | |
dc.contributor.author | TROLLOR, Julian N. | |
dc.contributor.author | VALDES HERNANDEZ, Maria C. | |
dc.contributor.author | VERNOOIJ, Meike W. | |
dc.contributor.author | VOLKER, Uwe | |
dc.contributor.author | WITTFELD, Katharina | |
dc.contributor.author | WONG, Tien Yin | |
dc.contributor.author | WRIGHT, Margaret J. | |
dc.contributor.author | ZHANG, Junyi | |
dc.contributor.author | ZHAO, Wanting | |
dc.contributor.author | ZHU, Yi-Cheng | |
dc.contributor.author | SCHMIDT, Helena | |
dc.contributor.author | SACHDEV, Perminder S. | |
dc.contributor.author | WEN, Wei | |
dc.contributor.author | YOSHIDA, Kazumichi | |
dc.contributor.author | JOUTEL, Anne | |
dc.contributor.author | SATIZABAL, Claudia L. | |
dc.contributor.author | SACCO, Ralph L. | |
dc.contributor.author | BOURQUE, Guillaume | |
dc.contributor.author | LATHROP, Mark | |
dc.contributor.author | PAUS, Tomas | |
dc.contributor.author | FERNANDEZ-CADENAS, Israel | |
dc.contributor.author | YANG, Qiong | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | MAZOYER, Bernard | |
dc.contributor.author | BOUTINAUD, Philippe | |
dc.contributor.author | OKADA, Yukinori | |
dc.contributor.author | GRABE, Hans J. | |
dc.contributor.author | MATHER, Karen A. | |
dc.contributor.author | SCHMIDT, Reinhold | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | JOLIOT, Marc | |
dc.contributor.author | IKRAM, M Arfan | |
dc.contributor.author | MATSUDA, Fumihiko | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TZOURIO, Christophe | |
dc.contributor.author | WARDLAW, Joanna M. | |
dc.contributor.author | SESHADRI, Sudha | |
dc.contributor.author | ADAMS, Hieab H. H. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DEBETTE, Stephanie | |
dc.date.accessioned | 2023-05-13T10:23:10Z | |
dc.date.available | 2023-05-13T10:23:10Z | |
dc.date.issued | 2023-04-17 | |
dc.identifier.issn | 1546-170X (Electronic) 1078-8956 (Print) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182095 | |
dc.description.abstractEn | Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter. These were associated with white matter PVS already in young adults (N = 1,748; 22.1 ± 2.3 yr) and were enriched in early-onset leukodystrophy genes and genes expressed in fetal brain endothelial cells, suggesting early-life mechanisms. In total, 53% of white matter PVS risk loci showed nominally significant associations (27% after multiple-testing correction) in a Japanese population-based cohort (N = 2,862; 68.3 ± 5.3 yr). Mendelian randomization supported causal associations of high blood pressure with basal ganglia and hippocampal PVS, and of basal ganglia PVS and hippocampal PVS with stroke, accounting for blood pressure. Our findings provide insight into the biology of PVS and cerebral small vessel disease, pointing to pathways involving extracellular matrix, membrane transport and developmental processes, and the potential for genetically informed prioritization of drug targets. | |
dc.description.sponsorship | Etude de cohorte sur la santé des étudiants | en_US |
dc.description.sponsorship | Stopping cognitive decline and dementia by fighting covert cerebral small vessel disease | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title.en | Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease | |
dc.title.alternative | Nat Med | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41591-023-02268-w | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 37069360 | en_US |
dc.description.sponsorshipEurope | Study on Environmental and GenomeWide predictors of early structural brain Alterations in Young students | en_US |
bordeaux.journal | Nature Medicine | en_US |
bordeaux.page | 950-962 | en_US |
bordeaux.volume | 29 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 4 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | HEALTHY_BPH | en_US |
bordeaux.team | ELEANOR_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04096692 | |
hal.version | 1 | |
hal.date.transferred | 2023-05-13T10:23:37Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Medicine&rft.date=2023-04-17&rft.volume=29&rft.issue=4&rft.spage=950-962&rft.epage=950-962&rft.eissn=1546-170X%20(Electronic)%201078-8956%20(Print)&rft.issn=1546-170X%20(Electronic)%201078-8956%20(Print)&rft.au=DUPERRON,%20Marie-Gabrielle&KNOL,%20Maria%20J.&LE%20GRAND,%20Quentin&EVANS,%20Tavia%20E.&MISHRA,%20Aniket&rft.genre=article | |