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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMILLE, Theo
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorQUILGARS, Camille
ORCID: 0000-0001-8751-0764
IDREF: 257528628
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCAZALETS, Jean-Rene
ORCID: 0000-0001-9047-3933
IDREF: 032170149
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBERTRAND, Sandrine
ORCID: 0000-0002-3020-7980
IDREF: 237520958
dc.date.accessioned2023-05-12T13:00:05Z
dc.date.available2023-05-12T13:00:05Z
dc.date.issued2021-02-01
dc.identifier.issn2051-817Xen_US
dc.identifier.urioai:crossref.org:10.14814/phy2.14736
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182086
dc.description.abstractEnThis article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine (ACh) in controlling the operation of locomotor neural networks within the spinal cord. This cholinergic system has the particularity of being completely intraspinal. We describe the different effects exerted by spinal cholinergic neurons on locomotor circuitry by the pharmacological activation or blockade of this propriospinal system, as well as describing its different cellular and subcellular targets. Through the activation of one ionotropic receptor, the nicotinic receptor, and five metabotropic receptors, the M1 to M5 muscarinic receptors, the cholinergic system exerts a powerful control both on synaptic transmission and locomotor network neuron excitability. Although tremendous advances have been made in our understanding of the spinal cholinergic system's involvement in the physiology and pathophysiology of locomotor networks, gaps still remain, including the precise role of the different subtypes of cholinergic neurons as well as their pre- and postsynaptic partners. Improving our knowledge of the propriospinal cholinergic system is of major relevance to finding new cellular targets and therapeutics in countering the debilitating effects of neurodegenerative diseases and restoring motor functions after spinal cord injury.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.title.enAcetylcholine and spinal locomotor networks: The insider
dc.typeArticle de revueen_US
dc.identifier.doi10.14814/phy2.14736en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33527727en_US
bordeaux.journalPhysiological Reportsen_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamCoordination et plasticité des générateurs spinauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physiological%20Reports&rft.date=2021-02-01&rft.volume=9&rft.issue=3&rft.eissn=2051-817X&rft.issn=2051-817X&rft.au=MILLE,%20Theo&QUILGARS,%20Camille&CAZALETS,%20Jean-Rene&BERTRAND,%20Sandrine&rft.genre=article


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