MILLE, Theo; QUILGARS, Camille; CAZALETS, Jean-Rene; BERTRAND, Sandrine

doi:10.14814/phy2.14736

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

QUILGARS, Camille

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

CAZALETS, Jean-Rene

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

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Physiological Reports. 2021-02-01, vol. 9, n° 3

Résumé en anglais

This article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine (ACh) in controlling the operation of locomotor neural networks within the spinal cord. This cholinergic system has the particularity of being completely intraspinal. We describe the different effects exerted by spinal cholinergic neurons on locomotor circuitry by the pharmacological activation or blockade of this propriospinal system, as well as describing its different cellular and subcellular targets. Through the activation of one ionotropic receptor, the nicotinic receptor, and five metabotropic receptors, the M1 to M5 muscarinic receptors, the cholinergic system exerts a powerful control both on synaptic transmission and locomotor network neuron excitability. Although tremendous advances have been made in our understanding of the spinal cholinergic system's involvement in the physiology and pathophysiology of locomotor networks, gaps still remain, including the precise role of the different subtypes of cholinergic neurons as well as their pre- and postsynaptic partners. Improving our knowledge of the propriospinal cholinergic system is of major relevance to finding new cellular targets and therapeutics in countering the debilitating effects of neurodegenerative diseases and restoring motor functions after spinal cord injury.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/182086

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http://dx.doi.org/10.14814/phy2.14736

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Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

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Acetylcholine and spinal locomotor networks: The insider

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