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A Bottom‐Up Approach to Red‐Emitting Molecular‐Based Nanoparticles with Natural Stealth Properties and their Use for Single‐Particle Tracking Deep in Brain Tissue

hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorROSENDALE, Morgane
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorFLORES, Jessica
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPAVIOLO, Chiara
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPAGANO, Paolo
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDANIEL, Jonathan
dc.contributor.authorFERREIRA, Joana
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorVERLHAC, Jean‐baptiste
dc.contributor.authorGROC, Laurent
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBLANCHARD‐DESCE, Mireille
dc.date.accessioned2023-05-12T10:36:13Z
dc.date.available2023-05-12T10:36:13Z
dc.date.issued2021-04-22
dc.identifier.issn0935-9648
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181509
dc.description.abstractEnFluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.
dc.description.sponsorshipRegulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.title.enA Bottom‐Up Approach to Red‐Emitting Molecular‐Based Nanoparticles with Natural Stealth Properties and their Use for Single‐Particle Tracking Deep in Brain Tissue
dc.typeArticle de revue
dc.identifier.doi10.1002/adma.202006644
dc.subject.halChimie
dc.subject.halSciences du Vivant [q-bio]
dc.description.sponsorshipEuropeFunctionalisation of ultra-bright all organic nanoparticles for super resolution imaging in intact brain preparations
dc.description.sponsorshipEuropeCombining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication
bordeaux.journalAdvanced Materials
bordeaux.page2006644
bordeaux.volume33
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.issue22
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03281914
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03281914v1
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