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Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorSINHA, Bidisha
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorKOESTER, Darius
hal.structure.identifierCompartimentation et dynamique cellulaires [CDC]
dc.contributor.authorRUEZ, Richard
hal.structure.identifierCompartimentation et dynamique cellulaires [CDC]
dc.contributor.authorGONNORD, Pauline
hal.structure.identifierCenter for Microscopy and Microanalysis - University of Queensland
dc.contributor.authorBASTIANI, Michele
hal.structure.identifierCenter for Microscopy and Microanalysis - University of Queensland
dc.contributor.authorABANKAWA, Daniel
hal.structure.identifierDarrmouth Medical School
dc.contributor.authorSTAN, Radu
hal.structure.identifierThérapie des maladies du muscle strié
dc.contributor.authorBUTLER-BROWNE, Gillian
hal.structure.identifierLaboratoire de Biochimie
dc.contributor.authorVEDIE, Benoît
hal.structure.identifierCompartimentation et dynamique cellulaires [CDC]
dc.contributor.authorJOHANNES, Ludger
hal.structure.identifierDepartment of Ultrastructural Research
dc.contributor.authorMORONE, Nobuhiro
hal.structure.identifierInstitute for Molecular Bioscience
dc.contributor.authorPARTON, Robert
hal.structure.identifierCompartimentation et dynamique cellulaires [CDC]
dc.contributor.authorRAPOSO, Graça
hal.structure.identifierLaboratoire de Physico-Chimie Théorique [LPCT]
dc.contributor.authorSENS, Pierre
hal.structure.identifierCompartimentation et dynamique cellulaires [CDC]
dc.contributor.authorLAMAZE, Christophe
hal.structure.identifierlp2n-04,lp2n-16
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorNASSOY, Pierre
dc.date.accessioned2023-05-12T10:22:26Z
dc.date.available2023-05-12T10:22:26Z
dc.date.created2010-01-07
dc.date.issued2011-02-04
dc.identifier.issn0092-8674
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181151
dc.description.abstractEnThe functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin-and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin-and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
dc.description.sponsorshipCellular responses to mechanical stress: interplay between membrane tension and membrane dynamics
dc.language.isoen
dc.publisherElsevier
dc.subject.enSIGNAL-REGULATED KINASE
dc.subject.enMEMBRANE TENSION
dc.subject.enDEPENDENT ACTIVATION
dc.subject.enENDOTHELIAL-CELLS
dc.subject.enIN-VITRO
dc.subject.enPROTEIN
dc.subject.enENDOCYTOSIS
dc.subject.enMUTATIONS
dc.subject.enMUSCLE
dc.subject.enGENE
dc.title.enCells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cell.2010.12.031
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalCell
bordeaux.page402-413
bordeaux.volume144
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.issue3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00821331
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00821331v1
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