CLOCHARD, Gwen-Jiro; MBENGUE, Aby; METTLING, Clément; DIOUF, Birane; FAURIE, Charlotte; SENE, Omar; CHANCEREL, Emilie; GUICHOUX, Erwan; HOLLARD, Guillaume; RAYMOND, Michel; WILLINGER, Marc

doi:10.21203/rs.3.rs-1968350/v1

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CLOCHARD, Gwen-Jiro
Centre de Recherche en Économie et Statistique [CREST]

MBENGUE, Aby
Université Gaston Berger de Saint-Louis Sénégal [UGB]

METTLING, Clément
Institut de génétique humaine [IGH]

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Scientific Reports. 2023, vol. 13 (622)

Nature Publishing Group

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It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despitethe involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able todemonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studiesgave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could bemodulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of theenvironmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.< Réduire

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The effect of the 7R allele on the DRD4 risk tolerance locus is independent of background risk in Senegalese fishermen

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