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Long-term results of autologous scaffold-free tissue-engineered vascular graft for hemodialysis access

dc.rights.licenseopenen_US
dc.contributor.authorWYSTRYCHOWSKI, Wojciech
dc.contributor.authorGARRIDO, Sergio A
dc.contributor.authorMARINI, Alicia
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDUSSERRE, Nathalie
dc.contributor.authorRADOCHONSKI, Sam
dc.contributor.authorZAGALSKI, Krzysztof
dc.contributor.authorANTONELLI, Jorge
dc.contributor.authorCANALIS, Manuel
dc.contributor.authorSAMMARTINO, Andrea
dc.contributor.authorDAROCHA, Zbigniew
dc.contributor.authorBACZYŃSKI, Ryszard
dc.contributor.authorCIERNIAK, Tomasz
dc.contributor.authorREGELE, Heinz
dc.contributor.authorDE LA FUENTE, Luis M
dc.contributor.authorCIERPKA, Lech
dc.contributor.authorMCALLISTER, Todd N
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorL'HEUREUX, Nicolas
dc.date.accessioned2023-04-05T11:40:28Z
dc.date.available2023-04-05T11:40:28Z
dc.date.issued2022-06-30
dc.identifier.issn1129-7298en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172790
dc.description.abstractEnBackground:The growing size of the end stage renal disease (ESRD) population highlights the need for effective dialysis access. Exhausted native vascular access options have led to increased use of catheters and prosthetic shunts, which are both associated with high risks of access failure and infection. Emerging alternatives include tissue-engineered vascular grafts (TEVG). Here we present the endpoint results for 10 ESRD patients with the scaffold-free tissue-engineered vascular access produced from sheets of extracellular matrix produced in vitro by human cells in culture.Methods:Grafts were implanted as arteriovenous shunts in 10 ESRD patients with a complex history of access failure. Follow-up included ultrasound control of graft morphology and function, dialysis efficiency, access failure, intervention rate, as well as immunohistochemical analysis of graft structure.Results:One patient died of unrelated causes and three shunts failed to become useable access grafts during the 3-month maturation phase. The 12-month primary and secondary patency for the other six shunts was 86%. Survival of six shunts functioning as the vascular access was 22?±?12?months with longest primary patency of 38.6?months. The dialysis event rate of 3.34 per patient-year decreased significantly with the use of this TEVG to 0.67.Conclusions:This living autologous tissue-engineered vascular graft seems to be an alternative to synthetic vascular access options, exhibiting advantages of native arteriovenous fistula.
dc.language.isoENen_US
dc.title.enLong-term results of autologous scaffold-free tissue-engineered vascular graft for hemodialysis access
dc.title.alternativeJ Vasc Accessen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/11297298221095994en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalThe Journal of Vascular Accessen_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04059414
hal.version1
hal.date.transferred2023-04-05T11:41:03Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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