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Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPASSIEUX, Renaud
dc.contributor.authorSUDRE, Guillaume
dc.contributor.authorMONTEMBAULT, Alexandra
dc.contributor.authorRENARD, Martine
dc.contributor.authorHAGEGE, Agnes
dc.contributor.authorALCOUFFE, Pierre
dc.contributor.authorHADDANE, Ali
dc.contributor.authorVANDESTEENE, Marie
dc.contributor.authorBOUCARD, Nadege
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBORDENAVE, Laurence
dc.contributor.authorDAVID, Laurent
dc.date.accessioned2023-03-30T12:16:44Z
dc.date.available2023-03-30T12:16:44Z
dc.date.issued2022-04-11
dc.identifier.issn1735-1748en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172664
dc.description.abstractEnThe wet spinning of cytocompatible, bioresorbable, and knittable chitosan (CTS) monofilaments would be advantageous for a variety of surgical applications. The complexation capacity of chitosan with Cu2+ or Zn2+ can be leveraged to enhance its antibacterial activity, but not at the expense of cytocompatibility. In this work, a wet-spinning process was adapted for the in situ incorporation of Cu2+ or Zn2+ with chitosan dopes to produce monofilaments at different drawing ratios (τtot) with various cation/glucosamine molar ratios, evaluated in the fibers (rCu,f and rZn,f). Cytocompatibility and antibacterial activity of wet-spun monofilaments were, respectively, quantified by in vitro live-dead assays on balb 3T3 and by different evaluations of the proliferation inhibition of Staphylococcus epidermidis (Gram+) and Escherichia coli (Gram−). Knittability was tested by a specific tensile test using a knitting needle and evaluated with an industrial knitting machine. It was found that rCu,f = 0.01 and rZn,f = 0.03 significantly increase the antibacterial activity without compromising cytocompatibility. Wet spinning with τtot = 1.6 allowed the production of knittable CTS-Cu monofilaments, as confirmed by knitting assays under industrial conditions.
dc.description.sponsorshipLignes synchrotron françaises à l'ESRF - ANR-11-EQPX-0010en_US
dc.language.isoENen_US
dc.subject.enchitosan
dc.subject.enwet-spinning
dc.subject.enknittability
dc.subject.encomplexation
dc.subject.enantibacterial
dc.subject.encytocompatibility
dc.title.enCytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+
dc.title.alternativeACS Biomater. Sci. Eng.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acsbiomaterials.2c00079en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAcs Biomaterials Science & Engineeringen_US
bordeaux.page1735-1748en_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acs%20Biomaterials%20Science%20&%20Engineering&rft.date=2022-04-11&rft.volume=8&rft.issue=4&rft.spage=1735-1748&rft.epage=1735-1748&rft.eissn=1735-1748&rft.issn=1735-1748&rft.au=PASSIEUX,%20Renaud&SUDRE,%20Guillaume&MONTEMBAULT,%20Alexandra&RENARD,%20Martine&HAGEGE,%20Agnes&rft.genre=article


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