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TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
hal.structure.identifierInstitut de génétique humaine [IGH]
dc.contributor.authorROSSITTO, Moira
hal.structure.identifierInstitut de génétique humaine [IGH]
dc.contributor.authorDEJARDIN, Stephanie
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorRANDS, Chris M
hal.structure.identifierInstitut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC]
dc.contributor.authorLE GRAS, Stephanie
hal.structure.identifierThe Francis Crick Institute [London]
dc.contributor.authorMIGALE, Roberta
hal.structure.identifierThe Francis Crick Institute [London]
dc.contributor.authorMAHMOUD REZA, Rafiee
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorNEIRIJNCK, Yasmine
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
dc.contributor.authorPRUVOST, Alain
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
dc.contributor.authorNGUYEN, Anvi Laetitia
hal.structure.identifierInstitut de Génétique Moléculaire de Montpellier [IGMM]
dc.contributor.authorBOSSIS, Guillaume
dc.contributor.authorCAMMAS, F.
dc.contributor.authorLE, Gallic, L.
dc.contributor.authorWILHELM, D.
dc.contributor.authorLOVELL-BADGE, R.
dc.contributor.authorBOIZET-BONHOURE, B.
dc.contributor.authorNEF, S.
dc.contributor.authorPOULAT, F.
dc.date.accessioned2023-03-02T08:21:07Z
dc.date.available2023-03-02T08:21:07Z
dc.date.issued2022-07-29
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172133
dc.description.abstractEnGonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. In the mouse ovary, oestrogen receptors and FOXL2 protect ovarian granulosa cells from transdifferentiation into Sertoli cells, their testicular counterpart. However, the mechanism underlying their protective effect is unknown. Here, we show that TRIM28 is required to prevent female-to-male sex reversal of the mouse ovary after birth. We found that upon loss of Trim28, ovarian granulosa cells transdifferentiate to Sertoli cells through an intermediate cell type, different from gonadal embryonic progenitors. TRIM28 is recruited on chromatin in the proximity of FOXL2 to maintain the ovarian pathway and to repress testicular-specific genes. The role of TRIM28 in ovarian maintenance depends on its E3-SUMO ligase activity that regulates the sex-specific SUMOylation profile of ovarian-specific genes. Our study identifies TRIM28 as a key factor in protecting the adult ovary from the testicular pathway. © 2022, The Author(s).
dc.description.sponsorshipRôle de TRIM28 dans le maintien de l'identité ovarienne et dans la détermination du sexeen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enTRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-022-32061-1en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35906245en_US
bordeaux.journalNature Communicationsen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2022-07-29&rft.volume=13&rft.issue=1&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=ROSSITTO,%20Moira&DEJARDIN,%20Stephanie&RANDS,%20Chris%20M&LE%20GRAS,%20Stephanie&MIGALE,%20Roberta&rft.genre=article


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