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A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

dc.rights.licenseopenen_US
hal.structure.identifierInstitute of Psychiatry, Psychology & Neuroscience, King's College London
dc.contributor.authorSFORZINI, Luca
hal.structure.identifierInstitute of Psychiatry, Psychology & Neuroscience, King's College London
dc.contributor.authorWORREL, Courtney
hal.structure.identifierInstitute of Psychiatry, Psychology & Neuroscience, King's College London
dc.contributor.authorKOSE, Melisa
dc.contributor.authorANDERSON, Ian M
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorAROLT, Volter
hal.structure.identifierDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus
dc.contributor.authorBAEUR, Michael
hal.structure.identifierThe Florey Institute of Neuroscience and Mental Health
dc.contributor.authorBAUNE, Bernhard T
dc.contributor.authorBLIER, P.
dc.contributor.authorCLEARE, A.J.
dc.contributor.authorCOWEN, P.J.
dc.contributor.authorDINAN, T.G.
dc.contributor.authorFAGIOLINI, A.
dc.contributor.authorFERRIER, I.N.
dc.contributor.authorHEGERL, U.
dc.contributor.authorKRYSTAL, A.D.
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorMCALLISTER-WILLIAMS, R.H.
dc.contributor.authorMCINTYRE, R.S.
dc.contributor.authorMEYER-LINDENBERG, A.
dc.contributor.authorMILLER, A.H.
dc.contributor.authorNEMEROFF, C.B.
dc.contributor.authorNORMANN, C.
dc.contributor.authorNUTT, D.
dc.contributor.authorPALLANTI, S.
dc.contributor.authorPANI, L.
dc.contributor.authorPENNINX, B.W.J.H.
dc.contributor.authorSCHATZBERG, A.F.
dc.contributor.authorSHELTON, R.C.
dc.contributor.authorYATHAM, L.N.
dc.contributor.authorYOUNG, A.H.
dc.contributor.authorZAHN, R.
dc.contributor.authorAISLAITNER, G.
dc.contributor.authorBUTLEN-DUCUING, F.
dc.contributor.authorFLETCHER, C.
dc.contributor.authorHABERKAMP, M.
dc.contributor.authorLAUGHREN, T.
dc.contributor.authorMÄNTYLÄ, F.-L.
dc.contributor.authorSCHRUERS, K.
dc.contributor.authorTHOMSON, A.
dc.contributor.authorARTEAGA-HENRÍQUEZ, G.
dc.contributor.authorBENEDETTI, F.
dc.contributor.authorCASH-GIBSON, L.
dc.contributor.authorCHAE, W.R.
dc.contributor.authorDE, Smedt, H.
dc.contributor.authorGOLD, S.M.
dc.contributor.authorHOOGENDIJK, W.J.G.
dc.contributor.authorMONDRAGÓN, V.J.
dc.contributor.authorMARON, E.
dc.contributor.authorMARTYNOWICZ, J.
dc.contributor.authorMELLONI, E.
dc.contributor.authorOTTE, C.
dc.contributor.authorPEREZ-FUENTES, G.
dc.contributor.authorPOLETTI, S.
dc.contributor.authorSCHMIDT, M.E.
dc.contributor.authorVAN DE KETTERIJ, E.
dc.contributor.authorWOO, K.
dc.contributor.authorFLOSSBACH, Y.
dc.contributor.authorRAMOS-QUIROGA, J.A.
dc.contributor.authorSAVITZ, A.J.
dc.contributor.authorPARIANTE, C.M.
dc.date.accessioned2023-02-27T10:59:46Z
dc.date.available2023-02-27T10:59:46Z
dc.date.issued2021-12
dc.identifier.issn1359-4184en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172103
dc.description.abstractEnCriteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD. © 2021, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enA Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41380-021-01381-xen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34907394en_US
dc.description.sponsorshipEuropeEU/EFPIA/Innovative Medicines Initiative 2 Joint Undertaking.en_US
bordeaux.journalMolecular Psychiatryen_US
bordeaux.page1286-1299en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04006126
hal.version1
hal.date.transferred2023-02-27T11:00:22Z
hal.exporttrue
dc.rights.ccCC BYen_US
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