dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GRASSET, Leslie | |
dc.contributor.author | POWER, Melinda C. | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | CRIVELLO, Fabrice | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TZOURIO, Christophe | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | CHENE, Genevieve | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DUFOUIL, Carole | |
dc.date.accessioned | 2023-02-22T08:52:47Z | |
dc.date.available | 2023-02-22T08:52:47Z | |
dc.date.issued | 2023-03-07 | |
dc.identifier.issn | 1875-8908 (Electronic) 1387-2877 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172052 | |
dc.description.abstractEn | BACKGROUND: The long-term effects of traumatic brain injury (TBI) with loss of consciousness (LOC) on magnetic resonance imaging (MRI) markers of brain health and on dementia risk are still debated. OBJECTIVE: To investigate the associations of history of TBI with LOC with incident dementia and neuroimaging markers of brain structure and small vessel disease lesions. METHODS: The analytical sample consisted in 4,144 participants aged 65 and older who were dementia-free at baseline from the Three City -Dijon study. History of TBI with LOC was self-reported at baseline. Clinical Dementia was assessed every two to three years, up to 12 years of follow-up. A subsample of 1,675 participants <80 years old underwent a brain MRI at baseline. We investigated the associations between history of TBI with LOC and 1) incident all cause and Alzheimer's disease (AD) dementia using illness-death models, and 2) neuroimaging markers at baseline. RESULTS: At baseline, 8.3% of the participants reported a history of TBI with LOC. In fully-adjusted models, participants with a history of TBI with LOC had no statistically significant differences in dementia risk (HR = 0.90, 95% CI = 0.60-1.36) or AD risk (HR = 1.03, 95% CI = 0.69-1.52), compared to participants without TBI history. History of TBI with LOC was associated with lower white matter volume (β= -4.58, p = 0.048), but not with other brain volumes, white matter hyperintensities volume, nor covert brain infarct. CONCLUSION: This study did not find evidence of an association between history of TBI with LOC and dementia or AD dementia risks over 12-year follow-up, brain atrophy, or markers of small vessel disease. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject.en | Alzheimer’s disease | |
dc.subject.en | Brain MRI | |
dc.subject.en | Dementia | |
dc.subject.en | Traumatic brain injury | |
dc.title.en | How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort | |
dc.title.alternative | J Alzheimers Dis | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.3233/JAD-220658 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 36710672 | en_US |
bordeaux.journal | Journal of Alzheimer's Disease | en_US |
bordeaux.page | 1-11 | en_US |
bordeaux.page | 183-193 | |
bordeaux.volume | 92 | |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 1 | |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | HEALTHY_BPH | en_US |
bordeaux.team | PHARES_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Université de Bordeaux | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Fondation Plan Alzheimer | en_US |
bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
bordeaux.identifier.funderID | Fondation de France | en_US |
bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
hal.identifier | hal-04000092 | |
hal.version | 1 | |
hal.date.transferred | 2023-02-22T08:52:52Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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