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Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCUSSOTTO, Sophia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELGADO, INES
hal.structure.identifierCentro de Investigación Biomédica en Red Salud Mental [Madrid] [CIBER-SAM]
dc.contributor.authorORIOLO, Giovanni
dc.contributor.authorKEMPER, JONAS
dc.contributor.authorBEGARIE, DIANE
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDEXPERT, SANDRA
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSAUVANT, Julie
hal.structure.identifierCHU Henri Mondor [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierCentro de Investigación Biomédica en Red Salud Mental [Madrid] [CIBER-SAM]
dc.contributor.authorMARTIN-SANTOS, Rocio
dc.contributor.authorSCHAEFER, Martin
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
dc.date.accessioned2023-01-11T09:58:24Z
dc.date.available2023-01-11T09:58:24Z
dc.date.issued2022-03-31
dc.identifier.issn1091-4269en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171653
dc.description.abstractEnBackground: Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)−3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and in humans. However, few studies to date have investigated the role of PUFAs in antidepressant response. The primary aim of this study was to assess the link between baseline PUFA composition and changes in depressive symptoms as well as antidepressant response in a multicenter study of depressed patients. Methods: Sixty depressed adults who met criteria for MDD according to DSM-IV-TR were recruited. Neuropsychiatric evaluations occurred at baseline and after 4 and 8 weeks of treatment with standard antidepressants, including escitalopram (N = 45), sertraline (N = 13) and venlafaxine (N = 2). At study endpoint, patients were stratified into responders (R) or non-responders (NR) based on their MADRS (Montgomery-Åsberg Depression Rating Scale) score. Baseline PUFA levels were assessed and their association with clinical response was determined. Results: Lower ω−3 PUFA levels were associated to worse baseline symptomatology. Baseline levels of PUFAs were significantly different between R and NR, with R exhibiting lower docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and ω−3 index; and higher ω-6/ω−3 ratio than NR before the start of antidepressant treatment. DHA levels as well as the ω−3 index and ω-6/ω−3 ratio significantly predicted response to antidepressants at study endpoint. Conclusions: These results show that baseline levels of PUFAs predict later response to standard antidepressants in depressed subjects. They suggest that PUFA intake and/or metabolism represent a novel modifiable tool for the management of unresponsive depressed patients. © 2022 Wiley Periodicals LLC.
dc.language.isoENen_US
dc.title.enLow omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/da.23257en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35357051en_US
bordeaux.journalDepression and Anxietyen_US
bordeaux.page407-418en_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03934210
hal.version1
hal.date.transferred2023-01-11T09:58:32Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Depression%20and%20Anxiety&rft.date=2022-03-31&rft.volume=39&rft.issue=5&rft.spage=407-418&rft.epage=407-418&rft.eissn=1091-4269&rft.issn=1091-4269&rft.au=CUSSOTTO,%20Sophia&DELGADO,%20INES&ORIOLO,%20Giovanni&KEMPER,%20JONAS&BEGARIE,%20DIANE&rft.genre=article


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