Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CUSSOTTO, Sophia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DELGADO, INES | |
| hal.structure.identifier | Centro de Investigación Biomédica en Red Salud Mental [Madrid] [CIBER-SAM] | |
| dc.contributor.author | ORIOLO, Giovanni | |
| dc.contributor.author | KEMPER, JONAS | |
| dc.contributor.author | BEGARIE, DIANE | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DEXPERT, SANDRA | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | SAUVANT, Julie | |
| hal.structure.identifier | CHU Henri Mondor [Créteil] | |
| hal.structure.identifier | IMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC] | |
| dc.contributor.author | LEBOYER, Marion | |
| hal.structure.identifier | Centre hospitalier Charles Perrens [Bordeaux] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AOUIZERATE, Bruno
IDREF: 069471851 | |
| hal.structure.identifier | Centro de Investigación Biomédica en Red Salud Mental [Madrid] [CIBER-SAM] | |
| dc.contributor.author | MARTIN-SANTOS, Rocio | |
| dc.contributor.author | SCHAEFER, Martin | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| dc.date.accessioned | 2023-01-11T09:58:24Z | |
| dc.date.available | 2023-01-11T09:58:24Z | |
| dc.date.issued | 2022-03-31 | |
| dc.identifier.issn | 1091-4269 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171653 | |
| dc.description.abstractEn | Background: Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)−3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and in humans. However, few studies to date have investigated the role of PUFAs in antidepressant response. The primary aim of this study was to assess the link between baseline PUFA composition and changes in depressive symptoms as well as antidepressant response in a multicenter study of depressed patients. Methods: Sixty depressed adults who met criteria for MDD according to DSM-IV-TR were recruited. Neuropsychiatric evaluations occurred at baseline and after 4 and 8 weeks of treatment with standard antidepressants, including escitalopram (N = 45), sertraline (N = 13) and venlafaxine (N = 2). At study endpoint, patients were stratified into responders (R) or non-responders (NR) based on their MADRS (Montgomery-Åsberg Depression Rating Scale) score. Baseline PUFA levels were assessed and their association with clinical response was determined. Results: Lower ω−3 PUFA levels were associated to worse baseline symptomatology. Baseline levels of PUFAs were significantly different between R and NR, with R exhibiting lower docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and ω−3 index; and higher ω-6/ω−3 ratio than NR before the start of antidepressant treatment. DHA levels as well as the ω−3 index and ω-6/ω−3 ratio significantly predicted response to antidepressants at study endpoint. Conclusions: These results show that baseline levels of PUFAs predict later response to standard antidepressants in depressed subjects. They suggest that PUFA intake and/or metabolism represent a novel modifiable tool for the management of unresponsive depressed patients. © 2022 Wiley Periodicals LLC. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/da.23257 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35357051 | en_US |
| bordeaux.journal | Depression and Anxiety | en_US |
| bordeaux.page | 407-418 | en_US |
| bordeaux.volume | 39 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03934210 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-01-11T09:58:32Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Depression%20and%20Anxiety&rft.date=2022-03-31&rft.volume=39&rft.issue=5&rft.spage=407-418&rft.epage=407-418&rft.eissn=1091-4269&rft.issn=1091-4269&rft.au=CUSSOTTO,%20Sophia&DELGADO,%20INES&ORIOLO,%20Giovanni&KEMPER,%20JONAS&BEGARIE,%20DIANE&rft.genre=article |
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