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Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons

dc.rights.licenseopenen_US
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorKOUKOULI, Fani
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorMONTMERLE, Martin
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorAGUIRRE, Andrea
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorDE BRITO VAN VELZE, Marcel
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorPEIXOTO, Jeremy
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorCHOUDHARY, Vikash
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVARILH, Marjorie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJULIO-KALAJZIC, Francisca
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorALLENE, Camille
hal.structure.identifierInstituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] [IRYCIS]
dc.contributor.authorMENDEZ, Pablo
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorZERLAUT, Yann
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.contributor.authorSCHLUTER, Olivier M.
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorREBOLA, Nelson
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorBACCI, Alberto
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorLOURENCO, Joana
dc.date.accessioned2022-12-21T08:35:24Z
dc.date.available2022-12-21T08:35:24Z
dc.date.issued2022-08-23
dc.identifier.issn00221-11247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171587
dc.description.abstractEnPerisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity and function of these elusive but prominent neocortical inhibitory neurons are unclear. We find that their connectivity pattern is visual area specific. Persistently active CB1 signaling suppresses GABA release from CB1 BCs in the medial secondary visual cortex (V2M), but not in the primary visual cortex (V1). Accordingly, in vivo, tonic CB1 signaling is responsible for higher but less coordinated PN activity in the V2M than in the V1. These differential firing dynamics in the V1 and V2M can be captured by a computational network model that incorporates visual-area-specific properties. Our results indicate a differential CB1-mediated mechanism controlling PN activity, suggesting an alternative connectivity scheme of a specific GABAergic circuit in different cortical areas. © 2022 The Author(s)
dc.description.sponsorshipInstitut de Neurosciences Translationnelles de Parisen_US
dc.description.sponsorshipContrôle inhibiteur des circuits corticauxen_US
dc.description.sponsorshipPériode critique du développement du cortex prefrontal.en_US
dc.description.sponsorshipEmpreintes cellulaire et moléculaires de la diversité synaptique à l'échelle nanométrique - ANR-17-CE16-0026en_US
dc.description.sponsorshipRôles de l'IL-1ß neuronal dans l'excitabilité des réseaux en condition non inflammatoire - ANR-18-CE16-0011en_US
dc.description.sponsorshipMécanismes synaptiques de l'orchestration des réseaux corticauxen_US
dc.description.sponsorshipInfrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciencesen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enNeuroscience
dc.subject.enEndocannabinoids
dc.subject.enInhibition
dc.subject.enInterneurons
dc.subject.enIn vivo spontaneous activity
dc.subject.enSynaptic transmission
dc.subject.enVisual cortex
dc.title.enVisual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons
dc.title.alternativeCell Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2022.111202en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36001978en_US
dc.description.sponsorshipEuropeH2O20 Marie Sk1odowska-Curie Actionsen_US
bordeaux.journalCell Reportsen_US
bordeaux.page111202en_US
bordeaux.volume40en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
bordeaux.identifier.funderIDBrain and Behavior Research Foundationen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2022-08-23&rft.volume=40&rft.issue=8&rft.spage=111202&rft.epage=111202&rft.eissn=00221-11247&rft.issn=00221-11247&rft.au=KOUKOULI,%20Fani&MONTMERLE,%20Martin&AGUIRRE,%20Andrea&DE%20BRITO%20VAN%20VELZE,%20Marcel&PEIXOTO,%20Jeremy&rft.genre=article


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