Characterisation of methylphenidate-induced excitation in midbrain dopamine neurons, an electrophysiological study in the rat brain
| dc.rights.license | open | en_US |
| hal.structure.identifier | De Montfort University [Leicester, United Kingdom] [DMU] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DI MICELI, Mathieu | |
| hal.structure.identifier | De Montfort University [Leicester, United Kingdom] [DMU] | |
| dc.contributor.author | OMOLOYE, Adesina | |
| hal.structure.identifier | De Montfort University [Leicester, United Kingdom] [DMU] | |
| dc.contributor.author | GRONIER, Benjamin | |
| dc.date.accessioned | 2022-12-12T10:42:21Z | |
| dc.date.available | 2022-12-12T10:42:21Z | |
| dc.date.issued | 2022-01-10 | |
| dc.identifier.issn | 0278-5846 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170556 | |
| dc.description.abstractEn | Methylphenidate (MPH) is a drug routinely used for patients with attention deficit and hyperactivity disorder (ADHD). Concerns arise about psychostimulant use, with dramatic increases in prescriptions. Besides, antipsychotic drugs are often administered in combination with MPH. In this study, we examine the consequences of MPH exposure in combination with dopamine D2 receptor antagonism (eticlopride) on midbrain dopaminergic neurons in anaesthetised rodents, using in vivo extracellular single-cell electrophysiology. As expected, we show that methylphenidate (2 mg/kg, i.v.) decreases the firing and bursting activities of ventral tegmental area (VTA) dopamine neurons, an effect that is reversed with eticlopride (0.2 mg/kg, i.v.). However, using such a paradigm, we observed higher firing and bursting activities than under baseline conditions. Furthermore, we demonstrate that such an effect is dependent on dual alpha-1 and dopamine D1 receptors, as well as glutamatergic transmission, through glutamate N-Methyl-D-aspartate (NMDA) receptor activation. Chronic MPH treatment during adolescence greatly dampens MPH-induced excitatory effects measured at adulthood. To conclude, we demonstrated here that a combination of methylphenidate and a dopamine D2 receptor antagonist produced long-lasting consequences on midbrain dopamine neurons, via glutamatergic-dependent mechanisms. © 2021 | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Methylphenidate | |
| dc.subject.en | Antipsychotics | |
| dc.subject.en | Dopamine | |
| dc.subject.en | Glutamatergic neurotransmission | |
| dc.title.en | Characterisation of methylphenidate-induced excitation in midbrain dopamine neurons, an electrophysiological study in the rat brain | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.pnpbp.2021.110406 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 34339759 | en_US |
| bordeaux.journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_US |
| bordeaux.volume | 112 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03894405 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-12-12T10:42:23Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Progress%20in%20Neuro-Psychopharmacology%20and%20Biological%20Psychiatry&rft.date=2022-01-10&rft.volume=112&rft.eissn=0278-5846&rft.issn=0278-5846&rft.au=DI%20MICELI,%20Mathieu&OMOLOYE,%20Adesina&GRONIER,%20Benjamin&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||