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Differential vulnerability of thalamic nuclei in multiple sclerosis

dc.rights.licenseopenen_US
dc.contributor.authorBLYAU, Simon
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOUBIYR, Ismail
dc.contributor.authorSARANATHAN, Manojkumar
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorCOUPE, Pierrick
dc.contributor.authorDELOIRE, Mathilde
dc.contributor.authorCHARRE-MORIN, Julie
dc.contributor.authorSAUBUSSE, Aurore
dc.contributor.authorZHANG, Bei
dc.contributor.authorRUTT, Brian
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBROCHET, Bruno
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
dc.date.accessioned2022-12-08T10:49:52Z
dc.date.available2022-12-08T10:49:52Z
dc.date.issued2022-08-12
dc.identifier.issn1352-4585en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170501
dc.description.abstractEnObjectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences. © The Author(s), 2022.
dc.language.isoENen_US
dc.subject.enMRI
dc.subject.enDifferential vulnerability
dc.subject.enSegmentation
dc.subject.enThalamic nuclei
dc.subject.enThalamus
dc.subject.enVolumetry
dc.title.enDifferential vulnerability of thalamic nuclei in multiple sclerosis
dc.title.alternativeMult Scleren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/13524585221114247en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35959722en_US
bordeaux.journalMultiple Sclerosis Journalen_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03889881
hal.version1
hal.date.transferred2022-12-08T10:50:00Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Multiple%20Sclerosis%20Journal&amp;rft.date=2022-08-12&amp;rft.eissn=1352-4585&amp;rft.issn=1352-4585&amp;rft.au=BLYAU,%20Simon&amp;KOUBIYR,%20Ismail&amp;SARANATHAN,%20Manojkumar&amp;COUPE,%20Pierrick&amp;DELOIRE,%20Mathilde&amp;rft.genre=article


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