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Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

dc.rights.licenseopenen_US
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorROUMES, Hélène
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorJOLLÉ, Charlotte
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBLANC, Jordy
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
hal.structure.identifierLaboratoire commun Imagerie Métabolique Multi-Noyaux Multi-Organes [I3M]
dc.contributor.authorBENKHALED, Imad
hal.structure.identifierUniversidade Federal do Rio Grande do Sul [Porto Alegre] [UFRGS]
dc.contributor.authorCHATAIN, Carolina Piletti
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMASSOT, Philippe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorRAFFARD, Gérard
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUCHAUD, Véronique
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBIRAN, Marc
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorPYTHOUD, Catherine
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
dc.contributor.authorDÉGLON, Nicole
hal.structure.identifierUniversidade Federal do Rio Grande do Sul [Porto Alegre] [UFRGS]
dc.contributor.authorZIMMER, Eduardo
hal.structure.identifierUniversité de Lausanne = University of Lausanne [UNIL]
hal.structure.identifierIschémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] [ IRTOMIT [Poitiers]]
dc.contributor.authorPELLERIN, Luc
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUZIER-SORE, Anne-Karine
dc.date.accessioned2022-11-24T14:43:56Z
dc.date.available2022-11-24T14:43:56Z
dc.date.issued2021-11-23
dc.identifier.issn0027-8424en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170383
dc.description.abstractEnSignificance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose availability, lactate shuttling from astrocytes to neurons via monocarboxylate transporters is necessary to give rise to the blood oxygen level-dependent signal (used as a surrogate marker for activation) in the rat cerebral cortex following whisker stimulation. Moreover, lactate shuttling turned out to be also essential for sustaining behavioral performance associated with activation of the rat barrel cortex. These findings call for a reappraisal of neuroenergetics and the role of astrocytes in determining brain activation and function.
dc.description.sponsorshipExploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012en_US
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003en_US
dc.description.sponsorshipTranslational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057en_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enBrain metabolism
dc.subject.enMonocarboxylate transporter
dc.subject.enfMRI
dc.subject.enMRS
dc.subject.enLearning and memory
dc.title.enLactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance
dc.typeArticle de revueen_US
dc.identifier.doi10.1073/pnas.2112466118en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
bordeaux.volume118en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue47en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03826912
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&rft.date=2021-11-23&rft.volume=118&rft.issue=47&rft.eissn=0027-8424&rft.issn=0027-8424&rft.au=ROUMES,%20H%C3%A9l%C3%A8ne&JOLL%C3%89,%20Charlotte&BLANC,%20Jordy&BENKHALED,%20Imad&CHATAIN,%20Carolina%20Piletti&rft.genre=article


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