Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance
BENKHALED, Imad
Centre de résonance magnétique des systèmes biologiques [CRMSB]
Laboratoire commun Imagerie Métabolique Multi-Noyaux Multi-Organes [I3M]
Centre de résonance magnétique des systèmes biologiques [CRMSB]
Laboratoire commun Imagerie Métabolique Multi-Noyaux Multi-Organes [I3M]
PELLERIN, Luc
Université de Lausanne = University of Lausanne [UNIL]
Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] [ IRTOMIT [Poitiers]]
< Reduce
Université de Lausanne = University of Lausanne [UNIL]
Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] [ IRTOMIT [Poitiers]]
Language
EN
Article de revue
This item was published in
Proceedings of the National Academy of Sciences of the United States of America. 2021-11-23, vol. 118, n° 47
English Abstract
Significance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose ...Read more >
Significance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose availability, lactate shuttling from astrocytes to neurons via monocarboxylate transporters is necessary to give rise to the blood oxygen level-dependent signal (used as a surrogate marker for activation) in the rat cerebral cortex following whisker stimulation. Moreover, lactate shuttling turned out to be also essential for sustaining behavioral performance associated with activation of the rat barrel cortex. These findings call for a reappraisal of neuroenergetics and the role of astrocytes in determining brain activation and function.Read less <
English Keywords
Brain metabolism
Monocarboxylate transporter
fMRI
MRS
Learning and memory
ANR Project
Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057