ROUMES, Hélène; JOLLÉ, Charlotte; BLANC, Jordy; BENKHALED, Imad; CHATAIN, Carolina Piletti; MASSOT, Philippe; RAFFARD, Gérard; BOUCHAUD, Véronique; BIRAN, Marc; PYTHOUD, Catherine; DÉGLON, Nicole; ZIMMER, Eduardo; PELLERIN, Luc; BOUZIER-SORE, Anne-Karine

doi:10.1073/pnas.2112466118

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ROUMES, Hélène
Centre de résonance magnétique des systèmes biologiques [CRMSB]

JOLLÉ, Charlotte
Université de Lausanne = University of Lausanne [UNIL]

BLANC, Jordy
Centre de résonance magnétique des systèmes biologiques [CRMSB]

Langue

Article de revue

Ce document a été publié dans

Proceedings of the National Academy of Sciences of the United States of America. 2021-11-23, vol. 118, n° 47

Résumé en anglais

Significance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose availability, lactate shuttling from astrocytes to neurons via monocarboxylate transporters is necessary to give rise to the blood oxygen level-dependent signal (used as a surrogate marker for activation) in the rat cerebral cortex following whisker stimulation. Moreover, lactate shuttling turned out to be also essential for sustaining behavioral performance associated with activation of the rat barrel cortex. These findings call for a reappraisal of neuroenergetics and the role of astrocytes in determining brain activation and function.< Réduire

Mots clés en anglais

Brain metabolism

Monocarboxylate transporter

fMRI

MRS

Learning and memory

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170383

DOI

http://dx.doi.org/10.1073/pnas.2112466118

Project ANR

Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057

Unités de recherche

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536