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dc.rights.licenseopenen_US
dc.contributor.authorRODRIGUEZ-IGLESIAS, Noelia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorNADJAR, Agnes
dc.contributor.authorSIERRA, Amanda
dc.contributor.authorVALERO, Jorge
dc.date.accessioned2022-11-04T10:26:43Z
dc.date.available2022-11-04T10:26:43Z
dc.date.issued2022-03-21
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170197
dc.description.abstractEnMaternal intake of omega-3 (n-3 PUFAs) and omega-6 (n-6 PUFAs) polyunsaturated fatty acids impacts hippocampal neurogenesis during development, an effect that may extend to adulthood by altering adult hippocampal neurogenesis (AHN). The n-3 PUFAs and n-6 PUFAs are precursors of inflammatory regulators that potentially affect AHN and glia. Additionally, n-3 PUFA dietary supplementation may present a sexually dimorphic action in the brain. Therefore, we postulated that dietary n-6/n-3 PUFA balance shapes the adult DG in a sex-dependent manner influencing AHN and glia. We test our hypothesis by feeding adult female and male mice with n-3 PUFA balanced or deficient diets. To analyze the immunomodulatory potential of the diets, we injected mice with the bacterial endotoxin lipopolysaccharide (LPS). LPS reduced neuroblast number, and its effect was exacerbated by the n-3 PUFA-deficient diet. The n-3 PUFA-deficient diet reduced the DG volume, AHN, microglia number, and surveilled volume. The diet effect on most mature neuroblasts was exclusively significant in female mice. Colocalization and multivariate analysis revealed an association between microglia and AHN, as well as the sexual dimorphic effect of diet. Our study reveals that female mice are more susceptible than males to the effect of dietary n-6/n-3 PUFA ratio on AHN and microglia. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAlpha Tocopherol
dc.subject.enAminobenzoic Acid
dc.subject.enArachidonic Acid
dc.subject.enBiotin
dc.subject.enCholine
dc.subject.enColecalciferol
dc.subject.enCyanocobalamin
dc.subject.enEndotoxin
dc.subject.enFatty Acid
dc.subject.enFolic Acid
dc.subject.enInositol
dc.subject.enLinoleic Acid
dc.subject.enLipopolysaccharide
dc.subject.enMethionine
dc.subject.enNicotinic Acid
dc.subject.enOmega 3 Fatty Acid
dc.subject.enOmega 6 Fatty Acid
dc.subject.enPantothenate Calcium
dc.subject.enPolyunsaturated Fatty Acid
dc.subject.enPyridoxine
dc.subject.enRetinol Acetate
dc.subject.enRiboflavin
dc.subject.enAdult
dc.subject.enAnimal Experiment
dc.subject.enAnimal Model
dc.subject.enAnimal Tissue
dc.subject.enArticle
dc.subject.enBrain Tissue
dc.subject.enConfocal Laser Scanning Microscopy
dc.subject.enControlled Study
dc.subject.enDiet Supplementation
dc.subject.enDrug Sensitivity
dc.subject.enEpifluorescence Microscopy
dc.subject.enFemale
dc.subject.enGas Chromatography
dc.subject.enGlia
dc.subject.enImage Segmentation
dc.subject.enImmunofluorescence
dc.subject.enImmunohistochemistry
dc.subject.enInflammation
dc.subject.enMale
dc.subject.enMicroglia
dc.subject.enMouse
dc.subject.enNervous System Development
dc.subject.enNeuroblast
dc.subject.enNeuroprotection
dc.subject.enNonhuman
dc.subject.enNutritional Deficiency
dc.subject.enSex Difference
dc.title.enSusceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
dc.title.alternativeInt J Mol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms23063399en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35328825en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.page3399en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFonds de recherche du Québec – Nature et technologiesen_US
bordeaux.identifier.funderIDIkerbasque, Basque Foundation for Scienceen_US
bordeaux.identifier.funderIDJunta de Castilla y Leónen_US
bordeaux.identifier.funderIDConseil Régional, Île-de-Franceen_US
hal.identifierhal-03839309
hal.version1
hal.date.transferred2022-11-04T10:26:46Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2022-03-21&rft.volume=23&rft.issue=6&rft.spage=3399&rft.epage=3399&rft.eissn=1661-6596&rft.issn=1661-6596&rft.au=RODRIGUEZ-IGLESIAS,%20Noelia&NADJAR,%20Agnes&SIERRA,%20Amanda&VALERO,%20Jorge&rft.genre=article


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