Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
| dc.rights.license | open | en_US |
| dc.contributor.author | RODRIGUEZ-IGLESIAS, Noelia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | NADJAR, Agnes | |
| dc.contributor.author | SIERRA, Amanda | |
| dc.contributor.author | VALERO, Jorge | |
| dc.date.accessioned | 2022-11-04T10:26:43Z | |
| dc.date.available | 2022-11-04T10:26:43Z | |
| dc.date.issued | 2022-03-21 | |
| dc.identifier.issn | 1661-6596 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170197 | |
| dc.description.abstractEn | Maternal intake of omega-3 (n-3 PUFAs) and omega-6 (n-6 PUFAs) polyunsaturated fatty acids impacts hippocampal neurogenesis during development, an effect that may extend to adulthood by altering adult hippocampal neurogenesis (AHN). The n-3 PUFAs and n-6 PUFAs are precursors of inflammatory regulators that potentially affect AHN and glia. Additionally, n-3 PUFA dietary supplementation may present a sexually dimorphic action in the brain. Therefore, we postulated that dietary n-6/n-3 PUFA balance shapes the adult DG in a sex-dependent manner influencing AHN and glia. We test our hypothesis by feeding adult female and male mice with n-3 PUFA balanced or deficient diets. To analyze the immunomodulatory potential of the diets, we injected mice with the bacterial endotoxin lipopolysaccharide (LPS). LPS reduced neuroblast number, and its effect was exacerbated by the n-3 PUFA-deficient diet. The n-3 PUFA-deficient diet reduced the DG volume, AHN, microglia number, and surveilled volume. The diet effect on most mature neuroblasts was exclusively significant in female mice. Colocalization and multivariate analysis revealed an association between microglia and AHN, as well as the sexual dimorphic effect of diet. Our study reveals that female mice are more susceptible than males to the effect of dietary n-6/n-3 PUFA ratio on AHN and microglia. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Alpha Tocopherol | |
| dc.subject.en | Aminobenzoic Acid | |
| dc.subject.en | Arachidonic Acid | |
| dc.subject.en | Biotin | |
| dc.subject.en | Choline | |
| dc.subject.en | Colecalciferol | |
| dc.subject.en | Cyanocobalamin | |
| dc.subject.en | Endotoxin | |
| dc.subject.en | Fatty Acid | |
| dc.subject.en | Folic Acid | |
| dc.subject.en | Inositol | |
| dc.subject.en | Linoleic Acid | |
| dc.subject.en | Lipopolysaccharide | |
| dc.subject.en | Methionine | |
| dc.subject.en | Nicotinic Acid | |
| dc.subject.en | Omega 3 Fatty Acid | |
| dc.subject.en | Omega 6 Fatty Acid | |
| dc.subject.en | Pantothenate Calcium | |
| dc.subject.en | Polyunsaturated Fatty Acid | |
| dc.subject.en | Pyridoxine | |
| dc.subject.en | Retinol Acetate | |
| dc.subject.en | Riboflavin | |
| dc.subject.en | Adult | |
| dc.subject.en | Animal Experiment | |
| dc.subject.en | Animal Model | |
| dc.subject.en | Animal Tissue | |
| dc.subject.en | Article | |
| dc.subject.en | Brain Tissue | |
| dc.subject.en | Confocal Laser Scanning Microscopy | |
| dc.subject.en | Controlled Study | |
| dc.subject.en | Diet Supplementation | |
| dc.subject.en | Drug Sensitivity | |
| dc.subject.en | Epifluorescence Microscopy | |
| dc.subject.en | Female | |
| dc.subject.en | Gas Chromatography | |
| dc.subject.en | Glia | |
| dc.subject.en | Image Segmentation | |
| dc.subject.en | Immunofluorescence | |
| dc.subject.en | Immunohistochemistry | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Male | |
| dc.subject.en | Microglia | |
| dc.subject.en | Mouse | |
| dc.subject.en | Nervous System Development | |
| dc.subject.en | Neuroblast | |
| dc.subject.en | Neuroprotection | |
| dc.subject.en | Nonhuman | |
| dc.subject.en | Nutritional Deficiency | |
| dc.subject.en | Sex Difference | |
| dc.title.en | Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia | |
| dc.title.alternative | Int J Mol Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/ijms23063399 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35328825 | en_US |
| bordeaux.journal | International Journal of Molecular Sciences | en_US |
| bordeaux.page | 3399 | en_US |
| bordeaux.volume | 23 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fonds de recherche du Québec – Nature et technologies | en_US |
| bordeaux.identifier.funderID | Ikerbasque, Basque Foundation for Science | en_US |
| bordeaux.identifier.funderID | Junta de Castilla y León | en_US |
| bordeaux.identifier.funderID | Conseil Régional, Île-de-France | en_US |
| hal.identifier | hal-03839309 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-11-04T10:26:46Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
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