BESONG-NDIKA, Jane; IVANOV, Konstantin I; HAFRÉN, Anders; MICHON, Thierry; MAKINEN, Kristiina

doi:10.1128/JVI.02915-14

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BESONG-NDIKA, Jane
Helsingin yliopisto = Helsingfors universitet = University of Helsinki

IVANOV, Konstantin I
Helsingin yliopisto = Helsingfors universitet = University of Helsinki

HAFRÉN, Anders
Helsingin yliopisto = Helsingfors universitet = University of Helsinki

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Journal of Virology. 2015, vol. 89, n° 8, p. 4237-48

American Society for Microbiology

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The main functions of the CP during potyvirus infection are to protect viral RNA from degradation and to transport it locally, systemically, and from host to host. Although virion assembly is a key step in the potyviral infectious cycle, little is known about how it is initiated and how viral RNA is selected for encapsidation. The results presented here suggest that CP-CP rather than CP-RNA interactions are predominantly involved in the sequestration of viral RNA away from translation. We propose that the cotranslational nature of these interactions may represent a mechanism for the selection of viral RNA for encapsidation. A better understanding of the mechanism of virion assembly may lead to development of crops resistant to potyviruses at the level of viral RNA encapsidation, thereby reducing the detrimental effects of potyvirus infections on food production.< Réduire

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Cotranslational coat protein-mediated inhibition of potyviral RNA translation.

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