DAL SANTO, Sylvia; STAMPFL, Hansjörg; KRASENSKY, Julia; KEMPA, Stefan; GIBON, Yves; PETUTSCHNIG, Elena; ROZHON, Wilfried; HEUCK, Alexander; CLAUSEN, Tim; JONAK, Claudia

doi:10.1105/tpc.112.101279

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

DAL SANTO, Sylvia
Gregor Mendel Institute of Molecular Plant Biology [GMI]

STAMPFL, Hansjörg
Gregor Mendel Institute of Molecular Plant Biology [GMI]

KRASENSKY, Julia
Gregor Mendel Institute of Molecular Plant Biology [GMI]

Langue

Article de revue

Ce document a été publié dans

The Plant cell. 2012, vol. 24, n° 8, p. 3380-3392

American Society of Plant Biologists (ASPB)

Résumé en anglais

Diverse stresses such as high salt conditions cause an increase in reactive oxygen species (ROS), necessitating a redox stress response. However, little is known about the signaling pathways that regulate the antioxidant system to counteract oxidative stress. Here, we show that a Glycogen Synthase Kinase3 from Arabidopsis thaliana (ASK alpha) regulates stress tolerance by activating Glc-6-phosphate dehydrogenase (G6PD), which is essential for maintaining the cellular redox balance. Loss of stress-activated ASK alpha leads to reduced G6PD activity, elevated levels of ROS, and enhanced sensitivity to salt stress. Conversely, plants overexpressing ASK alpha have increased G6PD activity and low levels of ROS in response to stress and are more tolerant to salt stress. ASK alpha stimulates the activity of a specific cytosolic G6PD isoform by phosphorylating the evolutionarily conserved Thr-467, which is implicated in cosubstrate binding. Our results reveal a novel mechanism of G6PD adaptive regulation that is critical for the cellular stress response.< Réduire

Métadonnées

Licence d’utilisation du document

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in <em>Arabidopsis</em>

Langue

Ce document a été publié dans

Résumé en anglais

DOI

Origine

Unités de recherche