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Revealing stiffening and brittling of chronic myelogenous leukemia hematopoietic primary cells through their temporal response to shear stress

hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorLAPERROUSAZ, B
dc.contributor.authorBERGUIGA, L
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorNICOLINI, F.E.
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorMARTINEZ-TORRES, C.
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARNEODO, A.
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
dc.contributor.authorMAGUER-SATTA, V.
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
dc.contributor.authorNICOLINI, Franck Emmanuel
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARGOUL, Françoise
dc.date.created2016-03-07
dc.date.issued2016-06-02
dc.identifier.issn1478-3967
dc.description.abstractEnCancer cell transformation is often accompanied by a modification of their viscoelastic properties. When capturing the stress-to-strain response of primary chronic myelogenous leukemia (CML) cells, from two data sets of CD34+ hematopoietic cells isolated from healthy and leukemic bone marrows, we show that the mean shear relaxation modulus increases upon cancer transformation. This stiffening of the cells comes along with local rupture events, detected as reinforced sharp local maxima of this modulus, suggesting that these cancer cells respond to a local mechanical stress by a cascade of local brittle failure events.
dc.description.sponsorshipPhysique de la morphogenèse des plantes: propriétés dynamiques et mécaniques de la paroi des cellules du méristème - ANR-10-BLAN-1516
dc.language.isoen
dc.publisherInstitute of Physics: Hybrid Open Access
dc.rights.urihttp://creativecommons.org/licenses/by-sa/
dc.subject.enviscoelasticity
dc.subject.encell mechanics
dc.subject.encancer stem cells
dc.subject.enwavelet transform analysis
dc.subject.enchronic myelogenous leukemia
dc.subject.enprimary cells
dc.title.enRevealing stiffening and brittling of chronic myelogenous leukemia hematopoietic primary cells through their temporal response to shear stress
dc.typeArticle de revue
dc.identifier.doi10.1088/1478-3975/13/3/03LT01
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalPhysical Biology
bordeaux.page06LT01 (1-6)
bordeaux.volume13
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-01343169
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01343169v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physical%20Biology&rft.date=2016-06-02&rft.volume=13&rft.issue=3&rft.spage=06LT01%20(1-6)&rft.epage=06LT01%20(1-6)&rft.eissn=1478-3967&rft.issn=1478-3967&rft.au=LAPERROUSAZ,%20B&BERGUIGA,%20L&NICOLINI,%20F.E.&MARTINEZ-TORRES,%20C.&ARNEODO,%20A.&rft.genre=article


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